INT137532

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEY2) protein binding transcription factor activity (HEY2) DNA binding (HEY2)
transcription factor binding (HEY2) cytoplasm (HEY2)
HEY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
monoamine 4 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
nMDA receptor antagonist 2 100.00 Very High Very High Very High
nMDA receptor 2 100.00 Very High Very High Very High
Antihyperalgesic 2 99.78 Very High Very High Very High
Hyperalgesia 10 99.08 Very High Very High Very High
Neuropathic pain 2 95.00 High High
Disease Link Frequency Relevance Heat
Pain 12 99.48 Very High Very High Very High
Hyperalgesia 10 99.48 Very High Very High Very High
Dizziness 2 96.36 Very High Very High Very High
Fatigue 2 95.80 Very High Very High Very High
Neuropathic Pain 2 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
Negative_regulation (inhibitor) of CHF3381 associated with pain, hyperalgesia, analgesic, antagonist, nmda receptor and monoamine
1) Confidence 0.31 Published 2006 Journal J Pain Section Title Doc Link 16885013 Disease Relevance 0.62 Pain Relevance 1.77
PERSPECTIVE: This article presents the antihyperalgesic effect of CHF3381, a new NMDA receptor antagonist and reversible MAO-A inhibitor, in a human pain model and might guide the proper selection of CHF3381 doses to be used in Phase 2 studies in patients with neuropathic pain.
Negative_regulation (inhibitor) of CHF3381 associated with pain, antihyperalgesic, nmda receptor antagonist and neuropathic pain
2) Confidence 0.27 Published 2006 Journal J Pain Section Abstract Doc Link 16885013 Disease Relevance 1.07 Pain Relevance 1.41

General Comments

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