INT13754

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.96
Pain Relevance 5.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1)
plasma membrane (Ap2m1)
Anatomy Link Frequency
tail 1
cortex 1
Ap2m1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 100.00 Very High Very High Very High
opioid receptor 10 100.00 Very High Very High Very High
Opioid 10 99.98 Very High Very High Very High
Enkephalin 14 99.76 Very High Very High Very High
opiate 3 99.72 Very High Very High Very High
agonist 7 98.94 Very High Very High Very High
Antinociceptive 2 98.58 Very High Very High Very High
tail-flick 10 95.82 Very High Very High Very High
analgesia 14 95.46 Very High Very High Very High
Analgesic 4 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lordosis 9 99.80 Very High Very High Very High
Heart Rate Under Development 5 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that binding to high-affinity mu 1 receptors exerts an inhibitory influence on lordosis, whereas binding to low-affinity mu 2 receptors or delta receptors exerts a facilitatory influence.
mu 2 Binding (binding) of associated with lordosis
1) Confidence 0.36 Published 1987 Journal Peptides Section Abstract Doc Link 3035514 Disease Relevance 0.66 Pain Relevance 0.34
These studies suggest that the vagal afferent-mediated antinociceptive and cardiovascular effects of i.v. morphine are primarily mediated by interactions with low affinity mu 2 opioid receptors.
mu 2 Binding (interactions) of associated with opioid receptor, antinociceptive and morphine
2) Confidence 0.36 Published 1993 Journal Brain Res. Section Abstract Doc Link 8096421 Disease Relevance 0.30 Pain Relevance 0.96
Mu1 binding was slightly more sensitive to the lesioning than mu2 binding.
mu2 Binding (binding) of
3) Confidence 0.35 Published 1988 Journal Life Sci. Section Abstract Doc Link 2848168 Disease Relevance 0 Pain Relevance 0.42
Gender differences were not observed for mu1, mu2, or delta binding in hypothalamus or cortex.
mu2 Binding (binding) of in cortex
4) Confidence 0.30 Published 1991 Journal Pain Section Abstract Doc Link 1677751 Disease Relevance 0 Pain Relevance 1.19
Since mu and delta opioid receptor subtypes have been implicated in supraspinal analgesia, the present study evaluated whether gender or adult gonadectomy altered (a) analgesia on the tail-flick and jump tests following central administration of the mu-selective agonist, [D-Ala2, Me-Phe4, Gly(ol)5] enkephalin (DAMGO) and the delta-selective agonist, [D-Ser2,Leu5] enkephalin-Thr6 (DSLET) and (b) mu1, mu2 and delta opioid receptor binding.
mu2 Binding (binding) of in tail associated with agonist, tail-flick, enkephalin, opioid receptor and analgesia
5) Confidence 0.30 Published 1991 Journal Pain Section Abstract Doc Link 1677751 Disease Relevance 0 Pain Relevance 1.32
Unlike most enkephalins and opiates, metkephamid binds equipotently to both morphine-selective (mu2) and enkephalin-selective (delta) binding sites.
mu2 Binding (binds) of associated with opiate, enkephalin and morphine
6) Confidence 0.19 Published 1982 Journal Peptides Section Abstract Doc Link 6294639 Disease Relevance 0 Pain Relevance 0.89
It is concluded that 3H-opioids bind to at least three sites--mu 1, mu 2 and delta.
mu 2 Binding (bind) of associated with opioid
7) Confidence 0.04 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.52

General Comments

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