INT137548

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.26
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Pygm) carbohydrate metabolic process (Pygm) cytoplasm (Pygm)
Anatomy Link Frequency
fibroblasts 1
lower legs 1
Pygm (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 24 98.70 Very High Very High Very High
cINOD 52 95.52 Very High Very High Very High
Inflammation 12 85.32 High High
Arthritis 2 52.32 Quite High
COX2 2 25.00 Low Low
visual analogue scale 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 24 98.70 Very High Very High Very High
Phosphate Metabolism Disorders 110 98.38 Very High Very High Very High
Reprotox - General 1 6 94.60 High High
INFLAMMATION 17 85.32 High High
Arthritis 2 52.32 Quite High
Fatigue 10 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 4 5.00 Very Low Very Low Very Low
Disorders Of Creatine Metabolism 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Muscle Weakness 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitriol significantly decreases the expression of the PG synthesizing cyclooxygenase-2 (COX-2) gene, while increasing that of PG inactivating 15-prostaglandin dehydrogenase (15-PGDH).
Positive_regulation (increasing) of PG
1) Confidence 0.04 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16886660 Disease Relevance 0.42 Pain Relevance 0.13
We hypothesized that the systemic elevation of PG levels seen in our patients was due to pyrophosphate stimulation of connective tissue cells including fibroblasts; PG synthesis by skin and synovial non-hypophosphatasia fibroblasts has already been established [14].
Positive_regulation (elevation) of PG in fibroblasts associated with phosphate metabolism disorders
2) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.89 Pain Relevance 0.41
Clinical features of childhood HP related to pain in the lower legs may be, at least in part, sequelae related to elevated PG levels, secondary to the primary metabolic defect.
Positive_regulation (elevated) of PG in lower legs associated with phosphate metabolism disorders and pain
3) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1533806 Disease Relevance 0.95 Pain Relevance 0.67

General Comments

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