INT137549

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.74
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Pygm) carbohydrate metabolic process (Pygm) cytoplasm (Pygm)
Anatomy Link Frequency
fibroblasts 3
lung 1
kidney 1
body 1
Pygm (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 210 98.92 Very High Very High Very High
Pain 98 94.48 High High
Inflammation 52 92.48 High High
withdrawal 8 89.72 High High
cva 16 66.32 Quite High
Arthritis 8 60.52 Quite High
antagonist 4 29.56 Quite Low
COX2 6 25.00 Low Low
visual analogue scale 16 5.00 Very Low Very Low Very Low
Analgesic 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Phosphate Metabolism Disorders 440 99.84 Very High Very High Very High
Hypertension 34 97.72 Very High Very High Very High
Reprotox - General 1 18 97.44 Very High Very High Very High
Pain 98 94.48 High High
Myocardial Infarction 2 92.92 High High
INFLAMMATION 73 92.48 High High
Coronary Heart Disease 4 88.84 High High
Asthma 4 88.72 High High
Targeted Disruption 20 76.08 Quite High
Injury 2 71.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main PG in the kidney is PGE2, which is synthesized from arachidonic acid (AA) by enzymatic reactions,
Gene_expression (synthesized) of PG in kidney
1) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.49 Pain Relevance 0.10
In the lung, significant reduction in BP was seen in PG EP1
Gene_expression (seen) of PG in lung
2) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.80 Pain Relevance 0.11
Calcitriol also inhibits the expression of the PG receptors EP2 and FP.
Gene_expression (expression) of PG
3) Confidence 0.04 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16886660 Disease Relevance 0.42 Pain Relevance 0.14
Calcitriol significantly decreases the expression of the PG synthesizing cyclooxygenase-2 (COX-2) gene, while increasing that of PG inactivating 15-prostaglandin dehydrogenase (15-PGDH).
Gene_expression (expression) of PG
4) Confidence 0.03 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16886660 Disease Relevance 0.43 Pain Relevance 0.11
Calcitriol significantly decreases the expression of the PG synthesizing cyclooxygenase-2 (COX-2) gene, while increasing that of PG inactivating 15-prostaglandin dehydrogenase (15-PGDH).
Gene_expression (synthesizing) of PG
5) Confidence 0.03 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16886660 Disease Relevance 0.42 Pain Relevance 0.12
When these latter two sets were compared, no significant difference was noted (3-way ANOVA, p = 0.62), indicating that PLP did not contribute significantly to the COX-2 gene induction and PG production.


Gene_expression (production) of PG
6) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.61 Pain Relevance 0
Calcium pyrophosphate, but not pyridoxal phosphate, induced cyclooxygenase-2 (COX-2) gene expression and PG production in HP and normal fibroblasts in vitro.


Gene_expression (production) of PG in fibroblasts associated with phosphate metabolism disorders
7) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1533806 Disease Relevance 1.17 Pain Relevance 0.71
We hypothesized that the systemic elevation of PG levels seen in our patients was due to pyrophosphate stimulation of connective tissue cells including fibroblasts; PG synthesis by skin and synovial non-hypophosphatasia fibroblasts has already been established [14].
Gene_expression (synthesis) of PG in fibroblasts associated with phosphate metabolism disorders
8) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.90 Pain Relevance 0.38
An excessive rebound of PG synthesis after cessation of COX blockade was not noted.
Gene_expression (synthesis) of PG
9) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.26 Pain Relevance 0.43
Prior to NSAID treatment, the urinary PGE2 levels, reflecting renal PG production, were essentially within the normal range.
Gene_expression (production) of PG associated with cinod
10) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.09 Pain Relevance 0.58
In order to avoid blocking PG synthesis for a long period of time, we now have investigated the effect of repeated NSAID treatments, each lasting 8 weeks, with an interval of four weeks in between.
Gene_expression (synthesis) of PG associated with cinod
11) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.87 Pain Relevance 0.45
-hydroxy-5,11-diketotetranorprosta-1,16-dioic acid (systemic index metabolite reflecting systemic levels of PGE2, PGE-M) was used as an indicator of total body PG production [25].
Gene_expression (production) of PG in body
12) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.21 Pain Relevance 0.03
Three-factorial analysis of variance (3-way ANOVA) was performed to describe differences in the COX-1, COX-2 gene expression, in addition to PG production of fibroblasts in vitro.
Gene_expression (production) of PG in fibroblasts
13) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.08 Pain Relevance 0

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