INT13755

Context Info Confidence 0.20 First Reported 1991 Last Reported 1991 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 1.32

plasma membrane (Oprd1, Ap2m1) lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency tail 1 Oprd1 (Rattus norvegicus) Ap2m1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 2 100.00 Enkephalin 3 99.46 agonist 3 98.94 tail-flick 2 95.82 analgesia 7 95.46 Morphine 1 81.28 Opioid 1 75.00 Analgesic 1 52.88

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since mu and delta opioid receptor subtypes have been implicated in supraspinal analgesia, the present study evaluated whether gender or adult gonadectomy altered (a) analgesia on the tail-flick and jump tests following central administration of the mu-selective agonist, [D-Ala2, Me-Phe4, Gly(ol)5] enkephalin (DAMGO) and the delta-selective agonist, [D-Ser2,Leu5] enkephalin-Thr6 (DSLET) and (b) mu1, mu2 and delta opioid receptor binding.

opioid receptor Binding (binding) of mu2 in tail associated with agonist, tail-flick, enkephalin, opioid receptor and analgesia

1) Confidence 0.20 Published 1991 Journal Pain Section Abstract Doc Link 1677751 Disease Relevance 0 Pain Relevance 1.32

General Comments

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