INT137556

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) oxidoreductase activity (Cyp19a1) endoplasmic reticulum (Cyp19a1)
cytoplasm (Cyp19a1)
Anatomy Link Frequency
heart 1
Cyp19a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 93.72 High High
sSRI 34 90.52 High High
Dopamine 5 80.76 Quite High
cocaine 1 76.08 Quite High
isoflurane 1 71.96 Quite High
anesthesia 1 71.12 Quite High
Catechol-O-methyltransferase 7 66.00 Quite High
cva 6 61.28 Quite High
agonist 7 51.08 Quite High
withdrawal 2 45.20 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 100.00 Very High Very High Very High
Stress 3 99.62 Very High Very High Very High
Coronary Artery Disease 1 98.36 Very High Very High Very High
Hypotension 1 90.12 High High
Breast Cancer 39 88.28 High High
Anxiety Disorder 209 85.52 High High
Congenital Anomalies 7 84.76 Quite High
Disorder Of Lipid Metabolism 2 75.00 Quite High
Cv General 3 Under Development 6 61.28 Quite High
Endometrial Cancer 6 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hill et al. [114] eliminated aromatase expression by targeted disruption of the Cyp19 gene, thereby producing estrogen deficient mice (designated ArKO mice).
Negative_regulation (disruption) of Cyp19 associated with targeted disruption
1) Confidence 0.35 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.59 Pain Relevance 0.27
Thus, despite an elevated resting aortic flow velocity and left ventricular contractility, cardiac functional reserve in response to dobutamine stress was significantly reduced in apoE-KO mice, which could be the consequence of coronary atherosclerosis and endothelial dysfunction that limits blood supply to the heart.
Negative_regulation (reduced) of apoE-KO in heart associated with stress and coronary artery disease
2) Confidence 0.24 Published 2006 Journal Transl Res Section Abstract Doc Link 16887496 Disease Relevance 0.58 Pain Relevance 0.11
Pharmacodynamic studies reveal that subjects receiving anastrozole 1 mg per day orally achieved 96.7% aromatase inhibition.11

Efficacy

Negative_regulation (achieved) of aromatase
3) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

This test has worked.

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