INT137593

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.59
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
gut 4
megakaryoblasts 2
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 11 100.00 Very High Very High Very High
Serotonin 47 98.08 Very High Very High Very High
Pain 59 95.80 Very High Very High Very High
spastic colon 17 94.32 High High
Opioid 18 92.76 High High
Analgesic 36 90.80 High High
sSRI 19 88.56 High High
Spinal cord 4 87.04 High High
Antinociceptive 5 85.52 High High
cerebral cortex 1 85.00 Quite High
Disease Link Frequency Relevance Heat
Pain 71 95.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 94.32 High High
Blister 1 93.36 High High
Nociception 4 89.08 High High
Functional Bowel Disorder 5 82.16 Quite High
Congenital Anomalies 2 74.52 Quite High
Appetite Loss 1 66.36 Quite High
Anxiety Disorder 10 65.28 Quite High
Fatigue 11 64.24 Quite High
Fibromyalgia 10 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also evidence that changes in the expression of SERT are due to a polymorphism in the transcription region in patients with FM [19].
Regulation (changes) of Gene_expression (expression) of SERT
1) Confidence 0.60 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.39 Pain Relevance 0.44
These results suggest that the effect of fluoxetine on the expression of hSERT is post-translational and has shown itself to be independent of PKC and PKA activity.
Regulation (effect) of Gene_expression (expression) of hSERT associated with fluoxetine
2) Confidence 0.59 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.12 Pain Relevance 0.86
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Regulation (role) of Gene_expression (expression) of SERT in gut
3) Confidence 0.54 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.23 Pain Relevance 1.00
In summary, we have shown herein that control megakaryoblasts express the SERT protein.
Regulation (control) of Gene_expression (express) of SERT protein in megakaryoblasts
4) Confidence 0.45 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.29 Pain Relevance 0.13
Moreover, chronic (48 h) exposure of cells to caffeine (1 microM) stimulated and chronic exposure to xanthohumol and iso-xanthohumol (1 and 0.1 microM, respectively) inhibited (3)H-thiamine uptake, these effects being not mediated through modulation of the expression levels of either hThTr-1 or hSERT mRNA.
Regulation (modulation) of Gene_expression (expression) of hSERT
5) Confidence 0.42 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 16889681 Disease Relevance 0 Pain Relevance 0.28
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Regulation (regulation) of Gene_expression (expression) of SERT in gut
6) Confidence 0.24 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.23 Pain Relevance 0.99
The serotonin transporter (5-HTT) is a key regulator of serotonin metabolism and availability and its gene harbors several known polymorphisms that are known to affect 5-HTT expression (e.g. 5-HTTLPR, rs25531).
Regulation (affect) of Gene_expression (expression) of 5-HTTLPR associated with serotonin
7) Confidence 0.24 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2717925 Disease Relevance 0.45 Pain Relevance 1.53

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