INT1376

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Context Info
Confidence 0.48
First Reported 1977
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 121
Total Number 127
Disease Relevance 20.00
Pain Relevance 69.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brain 17
spinal cord 11
amygdala 6
pituitary 5
nucleus 4
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 180 100.00 Very High Very High Very High
Enkephalin 140 100.00 Very High Very High Very High
Morphine 81 100.00 Very High Very High Very High
substance P 75 100.00 Very High Very High Very High
tolerance 24 100.00 Very High Very High Very High
anesthesia 19 100.00 Very High Very High Very High
opioid receptor 15 100.00 Very High Very High Very High
Serotonin 10 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
5HT 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 12 99.92 Very High Very High Very High
Convulsion 37 99.80 Very High Very High Very High
Low Back Pain 8 99.80 Very High Very High Very High
Pituitary Cancer 23 99.76 Very High Very High Very High
Bordatella Infection 17 99.76 Very High Very High Very High
Ulcers 12 99.40 Very High Very High Very High
Stress 88 99.26 Very High Very High Very High
Anaphylaxis 2 99.20 Very High Very High Very High
Pain 17 98.88 Very High Very High Very High
Hemorrhage 2 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thyrotropin-releasing hormone (TRH) has been recognized as a neuromodulator in several CNS regions, including the thoracolumbar spinal cord where an influence on cardiovascular autonomic function has been proposed.
Thyrotropin-releasing hormone Binding (recognized) of in spinal cord associated with spinal cord
1) Confidence 0.48 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9310457 Disease Relevance 0 Pain Relevance 0.08
Thyrotropin-releasing hormone (TRH) has been recognized as a neuromodulator in several CNS regions, including the thoracolumbar spinal cord where an influence on cardiovascular autonomic function has been proposed.
TRH Binding (recognized) of in spinal cord associated with spinal cord
2) Confidence 0.48 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9310457 Disease Relevance 0 Pain Relevance 0.08
TRH may interact with the opioid systems as its antinociceptive effect was blocked by pretreatment with naloxone.
TRH Binding (interact) of associated with narcan, antinociceptive and opioid
3) Confidence 0.48 Published 1989 Journal Pain Section Abstract Doc Link 2506505 Disease Relevance 0 Pain Relevance 0.62
Unidirectional interaction between thyrotropin releasing hormone and opiates at the level of their brain receptors.
thyrotropin releasing hormone Binding (interaction) of in brain associated with opiate
4) Confidence 0.48 Published 1987 Journal Gen. Pharmacol. Section Title Doc Link 3030873 Disease Relevance 0 Pain Relevance 0.52
Since previous studies from this laboratory indicate that the drugs acting at the kappa, and delta opiate receptors inhibit the binding of [3H](3-MeHis2) TRH to brain TRH receptors, the present studies suggest a unidirectional interaction between opiates and TRH in the brain at the level of their receptors.
TRH Binding (interaction) of in brain associated with opiate
5) Confidence 0.48 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3030873 Disease Relevance 0 Pain Relevance 0.52
It is concluded that TRH shortens the duration of propofol anesthesia, probably due to a pharmacodynamic effect and not to a pharmacokinetic interaction.
TRH Binding (interaction) of associated with anesthesia
6) Confidence 0.48 Published 1996 Journal Peptides Section Abstract Doc Link 8801536 Disease Relevance 0 Pain Relevance 0.53
Accumulating evidence exists regarding the interaction of serotonin (5HT) with TRH containing neuronal systems.
TRH Binding (interaction) of in neuronal associated with 5ht and serotonin
7) Confidence 0.48 Published 1992 Journal Regul. Pept. Section Abstract Doc Link 1574606 Disease Relevance 0 Pain Relevance 0.46
TRH seems to interact with central M-cholinergic system.
TRH Binding (interact) of
8) Confidence 0.48 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6412782 Disease Relevance 0.35 Pain Relevance 0.17
Agonist binding assays revealed that none of the these LAs affected TRH receptor binding.
TRH Binding (binding) of associated with agonist and local anesthetic
9) Confidence 0.48 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9882709 Disease Relevance 0.21 Pain Relevance 0.97
Interactions between the TRH changes we observed and other known regulatory changes in striatal neurotransmission are likely to be important [5], [54], [55], [56].
TRH Binding (Interactions) of
10) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.62 Pain Relevance 0.16
Thyrotropin releasing hormone (TRH) interacts with both opioid and non-opioid systems in mediating hypothermic, hypoactive, cataleptic, respiratory and analgesic effects.
Thyrotropin releasing hormone Binding (interacts) of in respiratory associated with analgesic and opioid
11) Confidence 0.48 Published 1984 Journal Peptides Section Abstract Doc Link 6433331 Disease Relevance 0.44 Pain Relevance 0.95
Thyrotropin releasing hormone (TRH) interacts with both opioid and non-opioid systems in mediating hypothermic, hypoactive, cataleptic, respiratory and analgesic effects.
TRH Binding (interacts) of in respiratory associated with analgesic and opioid
12) Confidence 0.48 Published 1984 Journal Peptides Section Abstract Doc Link 6433331 Disease Relevance 0.44 Pain Relevance 0.95
In contrast, preincubation of membranes with YM14673 caused dose-dependent decreases in TRH binding.
TRH Binding (binding) of
13) Confidence 0.48 Published 1995 Journal Endocr. Res. Section Abstract Doc Link 8582330 Disease Relevance 0 Pain Relevance 0.19
Affections of YM14673 on TRH binding were observed when cerebral cortical membranes were studied; those were not seen in membranes prepared from hypothalamus, striatum, midbrain, hippocampus, or pons-medulla.
TRH Binding (binding) of in medulla associated with medulla, hippocampus and midbrain
14) Confidence 0.48 Published 1995 Journal Endocr. Res. Section Abstract Doc Link 8582330 Disease Relevance 0 Pain Relevance 0.24
The results of this study show for the first time that the opiate antagonist-induced upregulation of opioid receptors is associated with modulation in binding of TRH receptors.
TRH Binding (binding) of associated with antagonist, opioid receptor and opiate
15) Confidence 0.48 Published 1988 Journal Neuropeptides Section Abstract Doc Link 2835703 Disease Relevance 0 Pain Relevance 0.50
The binding of 3H-(3-MeHis2) thyrotropin releasing hormone to brain and pituitary membranes of morphine tolerant-dependent and abstinent rats.
thyrotropin releasing hormone Binding (binding) of in pituitary associated with narcan and morphine
16) Confidence 0.48 Published 1989 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 2516632 Disease Relevance 0.08 Pain Relevance 0.86
Scatchard analysis indicated that the decrease in TRH binding is due to the decrease in the number of receptors.
TRH Binding (binding) of
17) Confidence 0.48 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 2431440 Disease Relevance 0.39 Pain Relevance 0.95
TRH receptor binding was decreased in the septum, amygdala + pyriform cortex and hypothalamus.
TRH Binding (binding) of in hypothalamus associated with amygdala
18) Confidence 0.48 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 2431440 Disease Relevance 0.39 Pain Relevance 1.00
Together with the present results, it appears that the inhibitory effect of TRH on morphine tolerance-dependence and abstinence is probably not mediated via central TRH receptors but may be due to its interaction with other neurotransmitter systems.
TRH Binding (interaction) of associated with addiction, neurotransmitter, tolerance and morphine
19) Confidence 0.48 Published 1990 Journal Peptides Section Abstract Doc Link 2172939 Disease Relevance 0 Pain Relevance 0.97
The results demonstrate for the first time that ligands acting at the delta- and kappa-opiate receptors interact with the brain TRH receptors; sigma-receptor ligands have weak interaction and mu-receptor ligands do not interact with brain TRH receptors.
TRH Neg (not) Binding (interact) of in brain associated with opiate
20) Confidence 0.48 Published 1986 Journal Brain Res. Section Abstract Doc Link 3008927 Disease Relevance 0 Pain Relevance 0.52

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