INT137602

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 1.10
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1A2) small molecule metabolic process (SULT1A2) cytoplasm (SULT1A2)
Anatomy Link Frequency
keratinocytes 5
embryos 1
skin 1
lung 1
SULT1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 84.48 Quite High
anesthesia 5 80.60 Quite High
agonist 104 40.04 Quite Low
Kinase C 32 21.92 Low Low
Bile 72 5.00 Very Low Very Low Very Low
Paracetamol 16 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Morphine 8 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 8 99.28 Very High Very High Very High
Cancer 8 98.86 Very High Very High Very High
INFLAMMATION 17 84.48 Quite High
Injury 1 72.92 Quite High
Ulcers 1 69.56 Quite High
Van Bogaert's Disease 56 5.00 Very Low Very Low Very Low
Toxicity 16 5.00 Very Low Very Low Very Low
Gallstones 16 5.00 Very Low Very Low Very Low
Sprains And Strains 16 5.00 Very Low Very Low Very Low
Syndrome 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single topical administration of a tumor promoter (e.g., phorbol ester) to mouse skin caused the induction of cholesterol sulfotransferase, the accumulation of cholesterol 3-sulfate, and the induction of transglutaminase-1 [62, 63].
Positive_regulation (induction) of sulfotransferase in skin associated with cancer
1) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.19 Pain Relevance 0
Cholesterol sulfotransferase activity was also induced during the culture of epidermal tissues isolated from 13.5-days, postcoitus mouse embryos with a time course that paralleled in vitro stratification [58].
Positive_regulation (induced) of sulfotransferase in embryos
2) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0
Cholesterol sulfotransferase activity was also elevated during epidermal wound healing [62].
Positive_regulation (elevated) of sulfotransferase associated with wound healing
3) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.19 Pain Relevance 0
Calcium-mediated differentiation of normal human keratinocytes was accompanied by the induction of two distinct sulfotransferase activities, cholesterol sulfotransferase, and minoxidil sulfotransferase [60].
Positive_regulation (induction) of sulfotransferase in keratinocytes
4) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.14 Pain Relevance 0
Calcium-mediated differentiation of normal human keratinocytes was accompanied by the induction of two distinct sulfotransferase activities, cholesterol sulfotransferase, and minoxidil sulfotransferase [60].
Positive_regulation (induction) of sulfotransferase in keratinocytes
5) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.13 Pain Relevance 0
Calcium-mediated differentiation of normal human keratinocytes was accompanied by the induction of two distinct sulfotransferase activities, cholesterol sulfotransferase, and minoxidil sulfotransferase [60].
Positive_regulation (induction) of sulfotransferase in keratinocytes
6) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.12 Pain Relevance 0
In monolayer cultures of normal human keratinocytes, confluence-mediated differentiation was accompanied by increased cholesterol sulfotransferase activity and accumulation of cholesterol 3-sulfate, with parallel increases in transglutaminase-1 [59].
Positive_regulation (increased) of sulfotransferase in keratinocytes
7) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.05 Pain Relevance 0
In monolayer cultures of normal human keratinocytes, confluence-mediated differentiation was accompanied by increased cholesterol sulfotransferase activity and accumulation of cholesterol 3-sulfate, with parallel increases in transglutaminase-1 [59].
Positive_regulation (accumulation) of sulfotransferase in keratinocytes
8) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.06 Pain Relevance 0
CS was found to be present in human lung, tracheal mucosa, and BALF, and a high synthesis of it was detected in the tracheal mucosa, in which cellular cholesterol sulfotransferase was induced depending on the density of tracheal cells.
Positive_regulation (induced) of sulfotransferase in lung
9) Confidence 0.03 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.23 Pain Relevance 0.34

General Comments

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