INT137602

Context Info Confidence 0.05 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 9 Disease Relevance 1.10 Pain Relevance 0.34

cytosol (SULT1A2) small molecule metabolic process (SULT1A2) cytoplasm (SULT1A2)

Anatomy Link Frequency keratinocytes 5 embryos 1 skin 1 lung 1 SULT1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 17 84.48 anesthesia 5 80.60 agonist 104 40.04 Kinase C 32 21.92 Bile 72 5.00 Paracetamol 16 5.00 dexamethasone 8 5.00 Morphine 8 5.00 Opioid 8 5.00

Disease Link Frequency Relevance Heat Wound Healing 8 99.28 Cancer 8 98.86 INFLAMMATION 17 84.48 Injury 1 72.92 Ulcers 1 69.56 Van Bogaert's Disease 56 5.00 Toxicity 16 5.00 Gallstones 16 5.00 Sprains And Strains 16 5.00 Syndrome 16 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A single topical administration of a tumor promoter (e.g., phorbol ester) to mouse skin caused the induction of cholesterol sulfotransferase, the accumulation of cholesterol 3-sulfate, and the induction of transglutaminase-1 [62, 63].

Positive_regulation (induction) of sulfotransferase in skin associated with cancer

1) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.19 Pain Relevance 0

Cholesterol sulfotransferase activity was also induced during the culture of epidermal tissues isolated from 13.5-days, postcoitus mouse embryos with a time course that paralleled in vitro stratification [58].

Positive_regulation (induced) of sulfotransferase in embryos

2) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0

Cholesterol sulfotransferase activity was also elevated during epidermal wound healing [62].

Positive_regulation (elevated) of sulfotransferase associated with wound healing

3) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.19 Pain Relevance 0

Calcium-mediated differentiation of normal human keratinocytes was accompanied by the induction of two distinct sulfotransferase activities, cholesterol sulfotransferase, and minoxidil sulfotransferase [60].

Positive_regulation (induction) of sulfotransferase in keratinocytes

4) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.14 Pain Relevance 0

Calcium-mediated differentiation of normal human keratinocytes was accompanied by the induction of two distinct sulfotransferase activities, cholesterol sulfotransferase, and minoxidil sulfotransferase [60].

Positive_regulation (induction) of sulfotransferase in keratinocytes

5) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.13 Pain Relevance 0

Calcium-mediated differentiation of normal human keratinocytes was accompanied by the induction of two distinct sulfotransferase activities, cholesterol sulfotransferase, and minoxidil sulfotransferase [60].

Positive_regulation (induction) of sulfotransferase in keratinocytes

6) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.12 Pain Relevance 0

In monolayer cultures of normal human keratinocytes, confluence-mediated differentiation was accompanied by increased cholesterol sulfotransferase activity and accumulation of cholesterol 3-sulfate, with parallel increases in transglutaminase-1 [59].

Positive_regulation (increased) of sulfotransferase in keratinocytes

7) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.05 Pain Relevance 0

In monolayer cultures of normal human keratinocytes, confluence-mediated differentiation was accompanied by increased cholesterol sulfotransferase activity and accumulation of cholesterol 3-sulfate, with parallel increases in transglutaminase-1 [59].

Positive_regulation (accumulation) of sulfotransferase in keratinocytes

8) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.06 Pain Relevance 0

CS was found to be present in human lung, tracheal mucosa, and BALF, and a high synthesis of it was detected in the tracheal mucosa, in which cellular cholesterol sulfotransferase was induced depending on the density of tracheal cells.

Positive_regulation (induced) of sulfotransferase in lung

9) Confidence 0.03 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.23 Pain Relevance 0.34

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