INT137607

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.72
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
fibroblasts 4
mast cell 4
endothelial cell 2
bladder 2
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 162 99.84 Very High Very High Very High
Inflammation 80 99.36 Very High Very High Very High
metalloproteinase 3 98.06 Very High Very High Very High
Cholecystokinin 1 94.64 High High
cytokine 29 90.40 High High
Angina 2 89.96 High High
Inflammatory response 4 80.40 Quite High
chemokine 2 77.44 Quite High
fibrosis 17 64.64 Quite High
imagery 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 32 99.98 Very High Very High Very High
Rheumatoid Arthritis 150 99.84 Very High Very High Very High
Pancreatic Cancer 1 99.76 Very High Very High Very High
INFLAMMATION 86 99.36 Very High Very High Very High
Reprotox - General 1 1 98.66 Very High Very High Very High
Disease Progression 3 97.24 Very High Very High Very High
Neuroendocrine Cancer 1 97.20 Very High Very High Very High
Arthritis 6 92.36 High High
Cv General 3 Under Development 1 89.96 High High
Disease 87 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
did not induce VEGF-A or IL-6 secretion, and in fact reduced VEGF-A levels and IL-6 in 4 out of 6 fibroblast lines.
Neg (not) Positive_regulation (induce) of Localization (secretion) of VEGF in fibroblast
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.42 Pain Relevance 0.30
did not induce VEGF-A secretion by RA synovial fibroblasts, which is in agreement with the lack of correlation between local Th1 cell frequency and PDUS signal.
Neg (not) Positive_regulation (induce) of Localization (secretion) of VEGF in fibroblasts associated with arthritis
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.62 Pain Relevance 0.31
For instance, PKD1 has been involved in secretion of matrix metalloproteinase-2 and -9 from prostate cancer cells [61] or of insulin [62]; PKD2 was shown to regulate hypoxia-induced VEGF-A secretion from pancreatic tumor cells [63] or secretion of chromogranin A from neuroendocrine tumor cells [64]; and PKD3 promoted secretion of cholecystokinin-mediated pancreatic amylase [65].
Positive_regulation (induced) of Localization (secretion) of VEGF associated with neuroendocrine cancer, hypoxia, pancreatic cancer, metalloproteinase, cholecystokinin and reprotox - general 1
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.47 Pain Relevance 0.10
CONCLUSIONS: Intravesical corticotropin-releasing hormone and acute restraint stress induced mast cell dependent vascular endothelial growth factor release from bladder explants.
Positive_regulation (induced) of Localization (release) of vascular endothelial growth factor in mast cell
4) Confidence 0.44 Published 2006 Journal J. Urol. Section Body Doc Link 16890727 Disease Relevance 0 Pain Relevance 0
RESULTS: Corticotropin-releasing hormone (100 nM) or acute restraint stress (4 hours) increased histamine release in urine and vascular endothelial growth factor release in medium without increasing interleukin-6 or tumor necrosis factor-alpha in the bladder explants of C57BL/6 or +/+ but not W/W(v) mice.
Positive_regulation (increased) of Localization (release) of vascular endothelial growth factor in bladder
5) Confidence 0.44 Published 2006 Journal J. Urol. Section Body Doc Link 16890727 Disease Relevance 0.05 Pain Relevance 0
As an alternative approach, low-dose irradiation has been shown to increase the release of vascular endothelial growth factor by activation of mast cells in an ischemic animal model, promoting vascular regeneration [45].
Positive_regulation (increase) of Localization (release) of vascular endothelial growth factor in mast cells
6) Confidence 0.28 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.11 Pain Relevance 0.06
AT II increases vascular permeability (by the release of prostaglandins and vascular endothelial cell growth factor or rearrangement of cytoskeletal proteins) that initiates the inflammatory process (Baylis and Brenner 1978; Ichikawa and Harris 1991; Schramek et al 1995).
Positive_regulation (increases) of Localization (release) of vascular endothelial cell growth factor in endothelial cell associated with inflammation
7) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 1.04 Pain Relevance 0.42

General Comments

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