INT137609

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 14.67
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
fibroblasts 4
bladder 3
endothelial cell 3
mast cell 3
Macrophage 1
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 64 100.00 Very High Very High Very High
Arthritis 243 99.84 Very High Very High Very High
ischemia 43 99.38 Very High Very High Very High
Pain 15 98.48 Very High Very High Very High
metalloproteinase 7 97.90 Very High Very High Very High
Inflammation 207 97.76 Very High Very High Very High
interstitial cystitis 5 97.48 Very High Very High Very High
fibrosis 23 95.84 Very High Very High Very High
Cholecystokinin 1 94.64 High High
Angina 2 88.36 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 225 99.84 Very High Very High Very High
Hypoxia 36 99.82 Very High Very High Very High
Pancreatic Cancer 1 99.76 Very High Very High Very High
Stress 57 99.74 Very High Very High Very High
Pituitary Cancer 4 99.68 Very High Very High Very High
Cv Unclassified Under Development 42 99.38 Very High Very High Very High
Diabetes Mellitus 94 99.08 Very High Very High Very High
Eye Disease 1 98.96 Very High Very High Very High
Reprotox - General 1 40 98.50 Very High Very High Very High
Bladder Disease 5 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
did not induce VEGF-A or IL-6 secretion, and in fact reduced VEGF-A levels and IL-6 in 4 out of 6 fibroblast lines.
Localization (secretion) of VEGF in fibroblast
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.42 Pain Relevance 0.30
To demonstrate a causal relationship between the presence of IL-17 producing cells within the joint and VEGF-A production, we cultured synovial fibroblasts (a known source of VEGF-A [26]) from 6 patients with RA with rIL-17 and measured secreted VEGF-A (Fig. 5D).
Localization (secreted) of VEGF in fibroblasts associated with arthritis
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.51 Pain Relevance 0.26
These cells express corticotropin-releasing hormone receptors with selective secretion of vascular endothelial growth factor, which may be involved in the pathogenesis of painful bladder syndrome/interstitial cystitis.
Localization (secretion) of vascular endothelial growth factor in bladder associated with pain, interstitial cystitis and bladder disease
3) Confidence 0.76 Published 2006 Journal J. Urol. Section Abstract Doc Link 16890727 Disease Relevance 0.45 Pain Relevance 0.24
RESULTS: Corticotropin-releasing hormone (100 nM) or acute restraint stress (4 hours) increased histamine release in urine and vascular endothelial growth factor release in medium without increasing interleukin-6 or tumor necrosis factor-alpha in the bladder explants of C57BL/6 or +/+ but not W/W(v) mice.
Localization (release) of vascular endothelial growth factor in bladder
4) Confidence 0.76 Published 2006 Journal J. Urol. Section Body Doc Link 16890727 Disease Relevance 0.05 Pain Relevance 0
The monocyte migration toward vascular endothelial growth factor-A and monocyte chemotactic protein-1 was strongly reduced in diabetic rabbits.
Localization (migration) of vascular endothelial growth factor-A in monocyte associated with diabetes mellitus
5) Confidence 0.73 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551694 Disease Relevance 1.03 Pain Relevance 0.04
did not induce VEGF-A secretion by RA synovial fibroblasts, which is in agreement with the lack of correlation between local Th1 cell frequency and PDUS signal.
Localization (secretion) of VEGF in fibroblasts associated with arthritis
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.62 Pain Relevance 0.30
For instance, PKD1 has been involved in secretion of matrix metalloproteinase-2 and -9 from prostate cancer cells [61] or of insulin [62]; PKD2 was shown to regulate hypoxia-induced VEGF-A secretion from pancreatic tumor cells [63] or secretion of chromogranin A from neuroendocrine tumor cells [64]; and PKD3 promoted secretion of cholecystokinin-mediated pancreatic amylase [65].
Localization (secretion) of VEGF associated with neuroendocrine cancer, hypoxia, pancreatic cancer, metalloproteinase, cholecystokinin and reprotox - general 1
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.47 Pain Relevance 0.10
CONCLUSIONS: Intravesical corticotropin-releasing hormone and acute restraint stress induced mast cell dependent vascular endothelial growth factor release from bladder explants.
Localization (release) of vascular endothelial growth factor in mast cell
8) Confidence 0.66 Published 2006 Journal J. Urol. Section Body Doc Link 16890727 Disease Relevance 0 Pain Relevance 0
We investigated the effect of intravesical corticotropin-releasing hormone and acute restraint stress on vascular endothelial growth factor release from mouse bladder explants and the role of mast cells.
Localization (release) of vascular endothelial growth factor in bladder associated with stress
9) Confidence 0.66 Published 2006 Journal J. Urol. Section Abstract Doc Link 16890727 Disease Relevance 0.55 Pain Relevance 0.23
Acute stress and intravesical corticotropin-releasing hormone induces mast cell dependent vascular endothelial growth factor release from mouse bladder explants.
Localization (release) of vascular endothelial growth factor in mast cell associated with stress
10) Confidence 0.66 Published 2006 Journal J. Urol. Section Title Doc Link 16890727 Disease Relevance 0.43 Pain Relevance 0.21
The VEGF 120 isoform is the main secreted protein form of VEGF with VEGF 164 encoding both a secreted and a membrane bound protein and VEGF 188 strictly being membrane bound [27].
Localization (secreted) of VEGF 188
11) Confidence 0.59 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.80 Pain Relevance 0.11
The VEGF 120 isoform is the main secreted protein form of VEGF with VEGF 164 encoding both a secreted and a membrane bound protein and VEGF 188 strictly being membrane bound [27].
Localization (secreted) of VEGF 164
12) Confidence 0.59 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.81 Pain Relevance 0.11
Rapamycin also inhibits vascular endothelial growth factor (VEGF) secretion and VEGF signaling in endothelial cells and impairs tumor growth by an antiangiogenic mechanism [9].
Localization (secretion) of vascular endothelial growth factor in endothelial cells associated with cancer
13) Confidence 0.44 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.11 Pain Relevance 0.08
Macrophage infiltration into ischemic tissues plays a key role in ischemia-induced neovascularization by releasing angiogenic cytokines including vascular endothelial growth factor (VEGF) [1], [2], [3], [4].
Localization (releasing) of vascular endothelial growth factor in Macrophage associated with ischemia and cytokine
14) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.63 Pain Relevance 0.27
As an alternative approach, low-dose irradiation has been shown to increase the release of vascular endothelial growth factor by activation of mast cells in an ischemic animal model, promoting vascular regeneration [45].
Localization (release) of vascular endothelial growth factor in mast cells
15) Confidence 0.33 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.10 Pain Relevance 0.06
Although endogenous lymphangiogenic inhibitors remain to be discovered, several secreted factors that promote corneal lymphangiogenesis have been identified recently, including members of the vascular endothelial growth factor (VEGF) family [9], fibroblast growth factor-2 [10], angiopoietin [11], platelet derived growth factor–BB [12], hepatocyte growth factor [13], and insulin-like growth factors [14].
Localization (secreted) of vascular endothelial growth factor in platelet
16) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.14 Pain Relevance 0.03
AT2R expression has been documented in blood vessels of human pituitary adenomas[12] and both the AT1R and AT2R stimulate vascular endothelial growth factor (VEGF) secretion by rat pituitary tumour cells [13].
Localization (secretion) of vascular endothelial growth factor in pituitary associated with pituitary cancer
17) Confidence 0.26 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.43 Pain Relevance 0.10
Secreted vascular endothelial growth factor (VEGF) was analyzed in the supernatant of cultivated tumour cells that had been maintained in serum-free medium for 24 to 48 hours [19].
Spec (analyzed) Localization (Secreted) of vascular endothelial growth factor associated with cancer
18) Confidence 0.24 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397521 Disease Relevance 0.10 Pain Relevance 0
Although the grade of leukocyte infiltration was similar among the genotypes by the end of the study, higher levels of both, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were secreted by TSP1?
Localization (secreted) of vascular endothelial growth factor in fibroblast
19) Confidence 0.19 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.26 Pain Relevance 0.12
Since increased secretion of vascular endothelial growth factor (VEGF) [4-6] has been observed in corneal NV as well as in other ocular neovascularization, some of the efforts have been directed at blocking VEGF or its endothelial cell-specific receptors, namely vascular endothelial growth factor receptor 1 (Flt-1) and vascular endothelial growth factor receptor 2 (Flk-1).
Localization (secretion) of endothelial growth factor in endothelial cell
20) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.58 Pain Relevance 0

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