INT137614

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 70
Total Number 114
Disease Relevance 66.13
Pain Relevance 12.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Lgals3) nucleus (Lgals3) extracellular matrix organization (Lgals3)
cytoplasm (Lgals3)
Anatomy Link Frequency
microglia 17
macrophages 10
heart 8
thyroid 6
liver 4
Lgals3 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 88 99.96 Very High Very High Very High
fibrosis 906 99.90 Very High Very High Very High
imagery 488 99.78 Very High Very High Very High
Inflammatory response 106 99.44 Very High Very High Very High
chemokine 13 99.40 Very High Very High Very High
Sciatic nerve 88 99.24 Very High Very High Very High
Nerve growth factor 2112 99.08 Very High Very High Very High
rheumatoid arthritis 52 98.40 Very High Very High Very High
Spinal cord 258 98.34 Very High Very High Very High
ischemia 88 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 396 100.00 Very High Very High Very High
Apoptosis 339 100.00 Very High Very High Very High
Injury 2021 99.96 Very High Very High Very High
Cancer 894 99.96 Very High Very High Very High
Targeted Disruption 160 99.96 Very High Very High Very High
Fibrosis 788 99.90 Very High Very High Very High
Obesity 141 99.84 Very High Very High Very High
Carcinoma 72 99.62 Very High Very High Very High
Coronary Heart Disease 41 99.62 Very High Very High Very High
Brain Injury 2068 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the in vivo expression of galectin-3 in tumor xenografts, some of the tumors were surgically excised and used for galectin-3 expression analysis as reported above.
Spec (determine) Gene_expression (expression) of galectin-3 associated with cancer
1) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.80 Pain Relevance 0.14
This was required for maintaining an efficient down-regulation of galectin-3 expression in stable interfered ARO cells, growing in vivo in absence of puromycine as selective antibiotic.
Gene_expression (expression) of galectin-3
2) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.49 Pain Relevance 0.03
A forced expression of galectin-3 via specific cDNA transfection generates a transformed phenotype, blocking the apoptotic program, a feature that favors the development of cancer [5]–[9].
Gene_expression (expression) of galectin-3 associated with cancer and apoptosis
3) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.79 Pain Relevance 0
To determine the in vivo expression of galectin-3 in tumor xenografts, some of the tumors were surgically excised and used for galectin-3 expression analysis as reported above.
Gene_expression (expression) of galectin-3 associated with cancer
4) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.73 Pain Relevance 0.13
Interestingly, as previously reported in a large multicentre retrospective study on histological material, well-differentiated thyroid carcinomas almost invariably express galectin-3 (>94% of all thyroid cancer types, with exclusion of the medullary carcinoma), while benign thyroid proliferations do not (only 2% of the benign nodules, mostly represented by adenomas, were galectin-3 positive) [10].
Gene_expression (express) of galectin-3 in thyroid associated with adenoma, thyroid neoplasm and carcinoma
5) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.91 Pain Relevance 0.03
Galectin-3 expressing and highly tumorigenic poorly differentiated follicular thyroid carcinoma cell line (ARO) and the derived galectin-3 knockout ARO cells (ARO-Gal3 negative) were considered for these experiments.
Gene_expression (expressing) of Galectin-3 in thyroid associated with targeted disruption and thyroid neoplasm
6) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.38 Pain Relevance 0.05
Normally thyroid cells do not express galectin-3.
Neg (not) Gene_expression (express) of galectin-3 in thyroid
7) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.77 Pain Relevance 0
This diagnostic approach may be also used for imaging different galectin-3 expressing tumors in vivo.


Gene_expression (expressing) of galectin-3 associated with cancer and imagery
8) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.88 Pain Relevance 0.10
The two following sequences, which strongly and similarly down regulated galectin-3 expression in ARO cells were sub-cloned into pSUPER vector and used interchangeably (conserved motifs are underlined): 5?
Gene_expression (expression) of galectin-3
9) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.32 Pain Relevance 0.06
However, expression of marker proteins for glia activation like major histocompatibility class II and galectin-3 was found to be affected.
Gene_expression (expression) of galectin-3
10) Confidence 0.72 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16890918 Disease Relevance 0.75 Pain Relevance 0.16
In support of a role for galectin-3/Mac-2 in active myelin phagocytosis, it was shown in a model of optic nerve injury, where myelin degradation and phagocytosis proceed slowly, that only a small subpopulation of microglia express galectin-3/Mac-2 [14].
Gene_expression (express) of Mac-2 in microglia associated with optic nerve injuries
11) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.82 Pain Relevance 0.22
There is emerging evidence that galectin-3/Mac-2-expressing microglia have roles beyond myelin phagocytosis.
Gene_expression (expressing) of Mac-2 in microglia
12) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.85 Pain Relevance 0.07
In the murine peripheral nervous system, sciatic nerve transection induces Schwann cells to express galectin-3/Mac-2 and phagocytose myelin [22].
Gene_expression (express) of Mac-2 in Schwann cells associated with peripheral nervous system and sciatic nerve
13) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.83 Pain Relevance 0.27
The authors observed that these two models differ in the degree of severity of injury and concluded that galectin-3/Mac-2 expression correlates with microglial activation in response to severe trauma [20].
Gene_expression (expression) of Mac-2 associated with injury
14) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.76 Pain Relevance 0.28
There is emerging evidence that galectin-3/Mac-2-expressing microglia have roles beyond myelin phagocytosis.
Gene_expression (expressing) of galectin-3 in microglia
15) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.85 Pain Relevance 0.07
The authors observed that these two models differ in the degree of severity of injury and concluded that galectin-3/Mac-2 expression correlates with microglial activation in response to severe trauma [20].
Gene_expression (expression) of galectin-3 associated with injury
16) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.76 Pain Relevance 0.28
In support of a role for galectin-3/Mac-2 in active myelin phagocytosis, it was shown in a model of optic nerve injury, where myelin degradation and phagocytosis proceed slowly, that only a small subpopulation of microglia express galectin-3/Mac-2 [14].
Gene_expression (express) of galectin-3 in microglia associated with optic nerve injuries
17) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.82 Pain Relevance 0.22
In contrast, after experimental allergic encephalomyelitis in mice, sites of demyelination within the spinal cord and optic nerve with active myelin degeneration and phagocytosis displayed robust expression of galectin-3/Mac-2 by resident microglia [23].
Gene_expression (expression) of galectin-3 in spinal cord associated with demyelination, experimental autoimmune encephalomyelitis and spinal cord
18) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.91 Pain Relevance 0.19
In contrast, after experimental allergic encephalomyelitis in mice, sites of demyelination within the spinal cord and optic nerve with active myelin degeneration and phagocytosis displayed robust expression of galectin-3/Mac-2 by resident microglia [23].
Gene_expression (expression) of Mac-2 in spinal cord associated with demyelination, experimental autoimmune encephalomyelitis and spinal cord
19) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.91 Pain Relevance 0.19
In the murine peripheral nervous system, sciatic nerve transection induces Schwann cells to express galectin-3/Mac-2 and phagocytose myelin [22].
Gene_expression (express) of galectin-3 in Schwann cells associated with peripheral nervous system and sciatic nerve
20) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.83 Pain Relevance 0.27

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