INT137629

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.42
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
brain 3
eye 2
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
alcohol 17 99.98 Very High Very High Very High
Kappa opioid receptor 2 99.04 Very High Very High Very High
mu opioid receptor 9 97.04 Very High Very High Very High
Intracerebroventricular 2 96.12 Very High Very High Very High
cocaine 9 95.60 Very High Very High Very High
Antinociceptive 2 94.76 High High
Somatostatin 17 88.84 High High
withdrawal 1 79.44 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 93.68 High High
Sprains And Strains 13 89.92 High High
Pressure And Volume Under Development 15 70.96 Quite High
Lifespan 33 50.00 Quite Low
INFLAMMATION 29 50.00 Quite Low
Vibrio Infection 5 32.72 Quite Low
Mental Disorders 1 30.68 Quite Low
Aids-related Complex 15 25.72 Quite Low
Ganglion Cysts 5 10.72 Low Low
Aging 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alcohol extract of ME was administered orally as suspension by triturating with 5% Tween 80.


ME Binding (extract) of associated with alcohol
1) Confidence 0.30 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC3013566 Disease Relevance 0.26 Pain Relevance 0.22
Here, we show that ME after eye-specific segregation induces the rearrangement of eye-specific patterns of RGC axons in the mouse dLGN.
ME Binding (segregation) of in eye
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.09 Pain Relevance 0
Consistent with Figure 1, the size of the gap was significantly smaller in ME-treated animals than in control animals (ME, 3.16±1.11%, n?
ME Binding (smaller) of
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Consistent with Figure 1, the size of the gap was significantly smaller in ME-treated animals than in control animals (ME, 3.16±1.11%, n?
ME Binding (smaller) of
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
These results indicate that ME after eye-specific segregation induces the rearrangement of RGC axons in the mouse dLGN.
ME Binding (segregation) of in eye
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.07 Pain Relevance 0
In these previous reports, however, quantitative information about ME-induced rearrangement was insufficient to answer a number of questions.
ME Binding (information) of
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Although we cannot conclude from our experiments, IGF receptors in the ME of adult bIGF1RKO+/?
ME Binding (receptors) of
7) Confidence 0.08 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.22
Immediately following testing, [3H]DAMGO (D-Ala2, N-Me-Phe4, Gly-ol5-enkephalin) receptor binding to brain homogenates was conducted.
N-Me-Phe4 Binding (binding) of in brain associated with enkephalin
8) Confidence 0.04 Published 2006 Journal Neuroscience Section Abstract Doc Link 16893609 Disease Relevance 0 Pain Relevance 0.78
The compound (100 microM) significantly decreased the specific binding of [3H]D-Ala2, N-Me-Phe4, Gly5-ol-enkephalin (DAMGO) and [3H]D-Pen2, D-Pen5-enkephalin (DPDPE) at the mu- and delta-opioid receptor, respectively, but has no effect on the binding of [3H]U-69,593 at the kappa-opioid receptor of rat brain slices.
N-Me-Phe4 Binding (binding) of in brain associated with kappa opioid receptor, opioid receptor and enkephalin
9) Confidence 0.00 Published 2005 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 18426082 Disease Relevance 0 Pain Relevance 0.46
The compound (100 microM) significantly decreased the specific binding of [3H]D-Ala2, N-Me-Phe4, Gly5-ol-enkephalin (DAMGO) and [3H]D-Pen2, D-Pen5-enkephalin (DPDPE) at the mu- and delta-opioid receptor, respectively, but has no effect on the binding of [3H]U-69,593 at the kappa-opioid receptor of rat brain slices.
N-Me-Phe4 Binding (binding) of in brain associated with kappa opioid receptor, opioid receptor and enkephalin
10) Confidence 0.00 Published 2005 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 18426082 Disease Relevance 0 Pain Relevance 0.47

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