INT137662

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd4) cytoplasm (Drd4) signal transducer activity (Drd4)
Drd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 152 100.00 Very High Very High Very High
monoamine 5 99.08 Very High Very High Very High
Serotonin 22 94.40 High High
alcohol 1 50.00 Quite Low
imagery 2 5.20 Low Low
midbrain 21 5.00 Very Low Very Low Very Low
Glutamate 20 5.00 Very Low Very Low Very Low
Nucleus accumbens 18 5.00 Very Low Very Low Very Low
Locus ceruleus 13 5.00 Very Low Very Low Very Low
nMDA receptor 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 163 99.68 Very High Very High Very High
Mental Disorders 1 70.24 Quite High
Cognitive Disorder 9 65.84 Quite High
Ocular Toxicity (including Many Sub-types) 11 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The non-treatment-seeking male and female heavy drinkers (62% alcohol dependent) were genotyped for the variable number of tandem repeats polymorphism in the DRD4 gene [L=7 or more (n=34), S=less than 7 (n=56)] and Asn40Asp single-nucleotide polymorphism in the OPRM1 gene [29 aspartate (Asp) carriers and 59 asparagine (Asn) homozygotes].
Negative_regulation (number) of DRD4 gene
1) Confidence 0.39 Published 2006 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 16899031 Disease Relevance 0 Pain Relevance 0
These include the dopamine D1, D4 and D5 receptor (DRD1, DRD4, DRD5) genes, the ?
Negative_regulation (include) of DRD4 associated with dopamine
2) Confidence 0.18 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.86 Pain Relevance 0.23

General Comments

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