INT137669

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 13 100.00 Very High Very High Very High
agonist 30 98.76 Very High Very High Very High
TRP channel 5 91.60 High High
imagery 1 84.08 Quite High
withdrawal 64 25.00 Low Low
Pain 6 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Root ganglion neuron 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 118 96.12 Very High Very High Very High
Sprains And Strains 2 51.24 Quite High
Pain 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that icilin activation of TRPM8 requires a product of iPLA2 activity perhaps acting as a cofactor that enables activation by icilin.
Positive_regulation (requires) of Positive_regulation (activation) of TRPM8
1) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.23 Pain Relevance 0.05
In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2.
Positive_regulation (dependent) of Positive_regulation (activation) of TRPM8
2) Confidence 0.46 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2822744 Disease Relevance 0.10 Pain Relevance 0.05
Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol.
Positive_regulation (activation) of Positive_regulation (activation) of TRPM8 associated with qutenza
3) Confidence 0.40 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.19

General Comments

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