INT137675

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.60
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Srpx2) cell motility (Srpx2) cell adhesion (Srpx2)
cytoplasm (Srpx2)
Srpx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 16 98.56 Very High Very High Very High
Bioavailability 2 90.96 High High
cINOD 8 73.96 Quite High
tricyclic antidepressant 4 57.84 Quite High
Pain 4 55.68 Quite High
diclofenac 6 49.72 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 2 96.32 Very High Very High Very High
INFLAMMATION 24 70.80 Quite High
Helminth Infection 4 69.72 Quite High
Sprains And Strains 4 67.32 Quite High
Chronic Obstructive Pulmonary Disease 2 61.60 Quite High
Autolysis 2 60.60 Quite High
Ulcers 2 56.24 Quite High
Arthritis 2 52.60 Quite High
Anaphylaxis 12 46.40 Quite Low
Pressure And Volume Under Development 16 43.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase C (PKC)-mediated phosphorylation of nascent chains at Thr-35 vastly decreased affinity for SRP binding suggesting an important regulatory step.
SRP Binding (affinity) of associated with kinase c
1) Confidence 0.37 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.26
Mutations Pro-2 --> Leu and Tyr-5 --> Leu, which increase the signal recognition particle (SRP) binding, diminished MT targeting of the protein in intact cells.
SRP Binding (binding) of
2) Confidence 0.37 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.14
With a view to select suitable dissolution medium for SRP, its stability in different media over a period of 12 h was evaluated.
SRP Binding (stability) of
3) Confidence 0.31 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883229 Disease Relevance 0.06 Pain Relevance 0
SRP can actually team up with antibiotics and deliver increased concentrations of antibiotics to the site of the infection.
SRP Binding (team) of associated with infection
4) Confidence 0.31 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883229 Disease Relevance 0.54 Pain Relevance 0.17
By contrast, mutations Leu-7 --> Asn and Leu-17 --> Asn, which decreased SRP-binding affinity, enhanced MT targeting, thus suggesting that SRP binding is an important regulatory step that modulates bimodal targeting.
SRP Binding (binding) of
5) Confidence 0.28 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.17
Protein kinase C (PKC)-mediated phosphorylation of nascent chains at Thr-35 vastly decreased affinity for SRP binding suggesting an important regulatory step.
SRP Binding (binding) of associated with kinase c
6) Confidence 0.27 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.26

General Comments

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