INT137677

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Anatomy Link Frequency
reticulum 2
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.98 Very High Very High Very High
Inflammation 1 75.68 Quite High
tricyclic antidepressant 1 73.92 Quite High
Pain 1 71.76 Quite High
Bioavailability 1 5.92 Low Low
agonist 8 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 93.80 High High
Targeted Disruption 18 84.72 Quite High
Malignant Neoplastic Disease 1 80.16 Quite High
Congenital Anomalies 1 78.16 Quite High
Toxicity 2 77.96 Quite High
INFLAMMATION 1 75.68 Quite High
Nicotine Addiction 8 70.52 Quite High
Obesity 3 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This molecular event results in transcriptional induction of downstream genes such as cytochrome P4501A1 (CYP1A1) that may generate mutagenic metabolites and reactive oxygen species (Nebert et al. 2000), leading to cellular activation, dysfunction, and/or programmed death.
Positive_regulation (results) of Positive_regulation (induction) of CYP1A1 associated with death
1) Confidence 0.07 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.56 Pain Relevance 0.04
In support of these results, COS cell transfection experiments show that phosphomimetic mutation Thr-35 --> Asp or induced cellular PKC caused increased CYP1A1 targeting to MT and correspondingly lower levels to the endoplasmic reticulum.
Positive_regulation (caused) of Positive_regulation (increased) of CYP1A1 in reticulum associated with kinase c
2) Confidence 0.06 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.29

General Comments

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