INT137679

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.58
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gfm1) intracellular (Gfm1) translation (Gfm1)
GTPase activity (Gfm1)
Anatomy Link Frequency
diaphragm 2
pore 1
astrocytes 1
vesicle 1
corpus luteum 1
Gfm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 40 99.72 Very High Very High Very High
Kinase C 4 99.26 Very High Very High Very High
Calcium channel 7 93.04 High High
Inflammation 80 89.64 High High
Catecholamine 5 88.72 High High
cerebral cortex 27 85.76 High High
ischemia 12 72.08 Quite High
Inflammatory response 27 54.48 Quite High
Hippocampus 27 53.92 Quite High
chemokine 21 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 10 99.60 Very High Very High Very High
Overdose 12 99.52 Very High Very High Very High
Apoptosis 163 99.44 Very High Very High Very High
Cancer 110 98.76 Very High Very High Very High
Necrosis 36 98.40 Very High Very High Very High
Stress 48 98.00 Very High Very High Very High
Emphysema 18 97.80 Very High Very High Very High
Death 130 96.28 Very High Very High Very High
Pulmonary Disease 28 95.80 Very High Very High Very High
Targeted Disruption 27 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, mitochondrial intermembrane proteins were released into the cytosol.
Localization (released) of mitochondrial
1) Confidence 0.08 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17906064 Disease Relevance 0.64 Pain Relevance 0.58
We concluded that the rapid mitochondrial Bax translocation after APAP overdose has no effect on peroxynitrite formation but that it contributes to the mitochondrial release of proteins, which cause nuclear DNA fragmentation.
Localization (release) of mitochondrial associated with paracetamol and overdose
2) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17906064 Disease Relevance 0.67 Pain Relevance 0.41
Because mitochondrial translocation of Bax can initiate these events, we investigated the potential role of Bax in the pathophysiology of hepatic necrosis after 300 mg/kg APAP in fasted C57BL/6 mice.
Localization (translocation) of mitochondrial associated with necrosis and paracetamol
3) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17906064 Disease Relevance 0.48 Pain Relevance 0.53
We concluded that the rapid mitochondrial Bax translocation after APAP overdose has no effect on peroxynitrite formation but that it contributes to the mitochondrial release of proteins, which cause nuclear DNA fragmentation.
Localization (translocation) of mitochondrial associated with paracetamol and overdose
4) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17906064 Disease Relevance 0.69 Pain Relevance 0.43
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
Localization (translocation) of Mitochondrial associated with necrosis, paracetamol and hepatotoxicity
5) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17906064 Disease Relevance 0.58 Pain Relevance 0.58
Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal.
Localization (translocation) of mitochondrial associated with kinase c
6) Confidence 0.06 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.11
We recently demonstrated that stimulation of G-protein coupled purinergic receptors (P2Y1Rs) increased Ca2+ sensitive mitochondrial metabolism in astrocytes [22].
Localization (metabolism) of mitochondrial in astrocytes
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.76 Pain Relevance 0.04
It has been demonstrated that pro-caspase-8 and pro-caspase-9 are predominantly localized in mitochondria which are released into cytoplasm upon permeabilization of the outer mitochondrial membrane upon apoptosis stimulation or oxidative stress [42], [43].
Localization (released) of mitochondrial associated with stress and apoptosis
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.93 Pain Relevance 0.03
Although coupling between COX-2 and mitochondrial enzymes in brain has not been reported, mitochondrial localization of COX-2 has been reported in cancer cells and in corpus luteum [12,13].
Localization (localization) of mitochondrial in corpus luteum associated with cancer
9) Confidence 0.04 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.10 Pain Relevance 0.13
It has recently been shown that the maximum rate of mitochondrial respiration and the efficiency of the electron transport chain for ATP production are increased in the diaphragm of COPD patients (Ribera et al 2002).
Localization (respiration) of mitochondrial in diaphragm associated with pulmonary disease
10) Confidence 0.03 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.34 Pain Relevance 0
This rate also seems to be dependent on species, because the maximum mitochondrial respiration rate reported by Ribera et al (2002) in human diaphragm was 5.28 ?
Localization (respiration) of mitochondrial in diaphragm
11) Confidence 0.03 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.30 Pain Relevance 0
revealed scattered expression in the cytoplasm, suggesting mitochondrial localization.
Localization (localization) of mitochondrial
12) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.72 Pain Relevance 0
This increase is probably due to acceleration of vesicle transport from a reserve pool to a ready-release vesicle pool; this transport might be controlled by Ca2+ redistribution to the cytoskeleton, through CICR, and/or mitochondrial Ca2+ release.
Localization (release) of mitochondrial in vesicle
13) Confidence 0.01 Published 2006 Journal Physiol. Rev. Section Abstract Doc Link 17015485 Disease Relevance 0 Pain Relevance 0.21
PINK1 regulates the mitochondrial localization of Parkin through its phosphorylation (Kim et al., 2008).
Localization (localization) of mitochondrial
14) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.60 Pain Relevance 0
The dye Mitotracker™ was used to confirm the mitochondrial localization of Rhod-2.
Localization (localization) of mitochondrial
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.07 Pain Relevance 0
The Bcl-2 family consists of both anti-apoptotic and pro-apoptotic proteins with the balance of these proteins regulating mitochondrial cytochrome c release.
Localization (release) of mitochondrial associated with apoptosis
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.24 Pain Relevance 0
However, both changes are conservative in terms of charge, and the A/Wuhan/359/1995 PB1-F2 shows mitochondrial localization by confocal microscopy (Figure S2).
Localization (localization) of mitochondrial
17) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.55 Pain Relevance 0.16
ANT3 and VDAC1 molecules are major components of the permeability transition pore of the mitochondrial membrane and enable cytochrome c release from the mitochondria, leading to the activation of the caspase pathway and subsequent cell death.
Localization (release) of mitochondrial in pore associated with death
18) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.89 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox