INT137688

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 1.21
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
neuropil 2
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 25 100.00 Very High Very High Very High
antagonist 5 99.52 Very High Very High Very High
Serotonin 15 98.76 Very High Very High Very High
depression 20 89.84 High High
antidepressant 5 85.48 High High
Disease Link Frequency Relevance Heat
Depression 20 89.84 High High
Adhesions 5 78.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that fluoxetine, acting through 5-HT3 receptors, can modulate PSA-NCAM expression in the mPFC.
Regulation (modulate) of Gene_expression (expression) of PSA-NCAM associated with fluoxetine
1) Confidence 0.60 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.17 Pain Relevance 0.72
The effects of fluoxetine treatment for 14 days on mPFC PSA-NCAM expression have also been analyzed.
Regulation (effects) of Gene_expression (expression) of PSA-NCAM associated with fluoxetine
2) Confidence 0.44 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.31 Pain Relevance 0.72
These results indicate that fluoxetine, acting through 5-HT3 receptors, can modulate PSA-NCAM expression in the mPFC.
Regulation (modulate) of Gene_expression (expression) of PSA-NCAM associated with fluoxetine
3) Confidence 0.44 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.17 Pain Relevance 0.72
The effects of fluoxetine treatment for 14 days on mPFC PSA-NCAM expression have also been analyzed.
Regulation (effects) of Gene_expression (expression) of PSA-NCAM associated with fluoxetine
4) Confidence 0.44 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.31 Pain Relevance 0.72
In general, chronic fluoxetine treatment induces significant increases in the number of PSA-NCAM immunoreactive neurons and in neuropil immunostaining and coadministration of the 5-HT3 antagonist ondansetron blocks the effects of fluoxetine on PSA-NCAM expression.
Regulation (effects) of Gene_expression (expression) of PSA-NCAM in neuropil associated with antagonist and fluoxetine
5) Confidence 0.23 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.24 Pain Relevance 0.77

General Comments

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