INT137690

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.37
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
ducts 2
neuropil 2
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 5 100.00 Very High Very High Very High
Inflammation 4 99.78 Very High Very High Very High
antagonist 1 99.74 Very High Very High Very High
Root ganglion neuron 1 99.00 Very High Very High Very High
spinal dorsal horn 1 97.56 Very High Very High Very High
Analgesic 8 96.76 Very High Very High Very High
Neuropathic pain 3 84.00 Quite High
Lasting pain 1 83.84 Quite High
Serotonin 3 81.28 Quite High
depression 4 78.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.78 Very High Very High Very High
Cancer 25 98.80 Very High Very High Very High
Primitive Neuroectodermal Tumors 19 98.76 Very High Very High Very High
Ganglion Cysts 1 98.68 Very High Very High Very High
Injury 4 97.68 Very High Very High Very High
Malignant Neoplastic Disease 4 90.04 High High
Carcinoma 3 88.76 High High
Neuropathic Pain 3 84.00 Quite High
Pain 1 83.84 Quite High
Disease 2 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of NCAM expression by NCAM antisense oligodeoxynucleotide administration to CCI rats abolished the analgesic effect of GDNF without affecting RET signaling activation.
Negative_regulation (Reduction) of Gene_expression (expression) of NCAM associated with analgesic and injury
1) Confidence 0.50 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 1.04 Pain Relevance 1.12
We suggested that CD56 expression is degenerative process in pancreatic tissue with chronic inflammation, and that examination of CD56 expression may be helpful in the differentiation of atypical degenerative ducts from cancerous ducts.
Spec (examination) Negative_regulation (examination) of Gene_expression (expression) of CD56 in ducts associated with inflammation
2) Confidence 0.40 Published 2006 Journal Kurume Med J Section Abstract Doc Link 17317933 Disease Relevance 0.92 Pain Relevance 0.26
In general, chronic fluoxetine treatment induces significant increases in the number of PSA-NCAM immunoreactive neurons and in neuropil immunostaining and coadministration of the 5-HT3 antagonist ondansetron blocks the effects of fluoxetine on PSA-NCAM expression.
Negative_regulation (blocks) of Gene_expression (expression) of PSA-NCAM in neuropil associated with antagonist and fluoxetine
3) Confidence 0.37 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.24 Pain Relevance 0.77
Immunohistochemical staining exhibited diffuse expression of the cluster of differentiation (CD) 99 (Figure 4) and CD56 antigens, but not the Wilms' tumour suppressor gene (WT1), indicating PNET as the most likely diagnosis.
Negative_regulation (exhibited) of Gene_expression (expression) of CD56 associated with cancer and primitive neuroectodermal tumors
4) Confidence 0.09 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2527024 Disease Relevance 1.17 Pain Relevance 0.03

General Comments

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