INT137691

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.30
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
medial 8
neuronal 4
telencephalon 4
neural 2
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 12 99.84 Very High Very High Very High
fluoxetine 31 99.78 Very High Very High Very High
antidepressant 18 99.78 Very High Very High Very High
amygdala 8 97.64 Very High Very High Very High
Somatosensory cortex 2 97.40 Very High Very High Very High
depression 21 94.36 High High
Hippocampus 5 87.84 High High
Pyramidal cell 1 58.80 Quite High
antagonist 4 48.24 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 9 100.00 Very High Very High Very High
Depression 21 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex.
Positive_regulation (increases) of Gene_expression (expression) of PSA-NCAM in medial associated with fluoxetine
1) Confidence 0.68 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 16900104 Disease Relevance 0.35 Pain Relevance 0.50
As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity.
Positive_regulation (increased) of Gene_expression (expression) of PSA-NCAM in neuronal associated with antidepressant, depression and serotonin
2) Confidence 0.68 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.37 Pain Relevance 0.46
Chronic fluoxetine treatment increases synaptophysin and PSA-NCAM expression in the medial prefrontal cortex and decreases them in the amygdala.
Positive_regulation (increases) of Gene_expression (expression) of PSA-NCAM in medial associated with amygdala and fluoxetine
3) Confidence 0.65 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.18 Pain Relevance 0.47
In a previous report we found that chronic fluoxetine treatment increases the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a molecule involved in neuronal structural plasticity, in the somatosensory cortex.
Positive_regulation (increases) of Gene_expression (expression) of PSA-NCAM in neural associated with somatosensory cortex, adhesions and fluoxetine
4) Confidence 0.57 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429152 Disease Relevance 0.19 Pain Relevance 0.49
As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity.
Positive_regulation (increased) of Gene_expression (expression) of PSA-NCAM in neuronal associated with antidepressant, depression and serotonin
5) Confidence 0.49 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.37 Pain Relevance 0.46
Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex.
Positive_regulation (increases) of Gene_expression (expression) of PSA-NCAM in medial associated with fluoxetine
6) Confidence 0.49 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 16900104 Disease Relevance 0.35 Pain Relevance 0.50
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Positive_regulation (induces) of Gene_expression (expression) of PSA-NCAM in telencephalon associated with antidepressant
7) Confidence 0.47 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.45
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Positive_regulation (induces) of Gene_expression (expression) of PSA-NCAM in telencephalon associated with antidepressant
8) Confidence 0.47 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.45
Chronic fluoxetine treatment increases synaptophysin and PSA-NCAM expression in the medial prefrontal cortex and decreases them in the amygdala.
Positive_regulation (increases) of Gene_expression (expression) of PSA-NCAM in medial associated with amygdala and fluoxetine
9) Confidence 0.47 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.18 Pain Relevance 0.47

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