INT137694

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tbx1) nucleus (Tbx1) DNA binding (Tbx1)
Tbx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 4 99.92 Very High Very High Very High
Digeorge Syndrome 20 98.06 Very High Very High Very High
Syndrome 4 75.00 Quite High
Schizophrenia 2 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, although deletion of the genes in the Lgdel region in mice may recapitulate some of the behavioral phenotypes seen in humans with VCFS/DGS, these phenotypes are not found in mice with complete loss of Gscl or in mice with heterozygous loss of Tbx1, suggesting that the neuropsychiatric and physical malformations of VCFS/DGS may act by different genetic mechanisms.
Negative_regulation (loss) of Tbx1 associated with digeorge syndrome
1) Confidence 0.59 Published 2006 Journal Neurogenetics Section Abstract Doc Link 16900388 Disease Relevance 0.73 Pain Relevance 0
Tbx1 +/- mice were impaired in grip strength similar to Lgdel/+ mice and movement initiation.
Negative_regulation (impaired) of Tbx1
2) Confidence 0.59 Published 2006 Journal Neurogenetics Section Abstract Doc Link 16900388 Disease Relevance 0.94 Pain Relevance 0

General Comments

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