INT137699

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (AR, PDYN) nucleoplasm (AR) transport (AR)
enzyme binding (AR) DNA binding (AR) cell-cell signaling (AR)
Anatomy Link Frequency
central nervous system 1
AR (Homo sapiens)
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 100.00 Very High Very High Very High
Antinociceptive 3 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Central nervous system 2 99.40 Very High Very High Very High
Spinal cord 1 98.48 Very High Very High Very High
noradrenaline 1 92.80 High High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 4 100.00 Very High Very High Very High
Cold Sores 5 98.36 Very High Very High Very High
Nociception 2 77.16 Quite High
Herpes Simplex Virus 2 75.00 Quite High
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that AR exerts antinociceptive effects on herpes-related pain through changes of the dynorphin levels in the central nervous system of HSV-inoculated mice.
AR Regulation (changes) of dynorphin in central nervous system associated with pain, cold sores, dynorphin, central nervous system and antinociceptive
1) Confidence 0.46 Published 2006 Journal In Vivo Section Abstract Doc Link 16900785 Disease Relevance 0.93 Pain Relevance 0.75

General Comments

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