INT1377

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2010
Negated 7
Speculated 3
Reported most in Abstract
Documents 172
Total Number 187
Disease Relevance 40.55
Pain Relevance 69.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
plasma 9
pituitary 8
hippocampus 6
thyroid 6
brain 5
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 109 100.00 Very High Very High Very High
substance P 79 100.00 Very High Very High Very High
Neuropeptide 66 100.00 Very High Very High Very High
medulla 48 100.00 Very High Very High Very High
amygdala 36 100.00 Very High Very High Very High
Intracerebroventricular 14 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
Morphine 110 99.98 Very High Very High Very High
cocaine 75 99.98 Very High Very High Very High
antinociception 8 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 79 100.00 Very High Very High Very High
Bordatella Infection 12 100.00 Very High Very High Very High
Convulsion 44 99.96 Very High Very High Very High
Thyroid Disease 55 99.84 Very High Very High Very High
Cluster Headache 8 99.58 Very High Very High Very High
Cognitive Disorder 5 99.56 Very High Very High Very High
Reprotox - General 1 20 99.52 Very High Very High Very High
Dyskinesias 478 99.40 Very High Very High Very High
Congenital Anomalies 53 99.04 Very High Very High Very High
Movement Disorders 14 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 72 h after the last morphine injection, the TRH level was increased in the striatum and hippocampus, but remained unchanged in the nucleus accumbens and septum.
Positive_regulation (increased) of TRH in hippocampus associated with nucleus accumbens, hippocampus and morphine
1) Confidence 0.70 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837962 Disease Relevance 0 Pain Relevance 0.84
DMI pretreatment blocked the increase in hippocampal TRH, but not in brainstem TRH.
Positive_regulation (increase) of TRH in brainstem associated with medulla
2) Confidence 0.70 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3928818 Disease Relevance 0 Pain Relevance 0.45
As shown by a specific radioimmunoassay, a single dose of morphine increased the TRH level in the septum only.
Positive_regulation (increased) of TRH associated with morphine
3) Confidence 0.70 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837962 Disease Relevance 0 Pain Relevance 0.69
Dose-dependent increases in TRH content following i.v.t. 5,7-DHT were noted in the brainstem and hippocampus.
Positive_regulation (increases) of TRH in hippocampus associated with medulla and hippocampus
4) Confidence 0.70 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3928818 Disease Relevance 0 Pain Relevance 0.44
FX pretreatment was ineffective in blocking any increases in TRH content.
Positive_regulation (increases) of TRH associated with fluoxetine
5) Confidence 0.70 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3928818 Disease Relevance 0 Pain Relevance 0.44
On the other hand, the increase in the hippocampal TRH level during both chronic cocaine and morphine withdrawal is a common feature of the mechanism of dependence on these drugs.
Positive_regulation (increase) of TRH associated with addiction, withdrawal, morphine and cocaine
6) Confidence 0.70 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.08 Pain Relevance 0.69
Repeated administration of cocaine increased the TRH level in the striatum by 89% at 45 min, and in the hippocampus by 26% at 72 h after the last dose.
Positive_regulation (increased) of TRH in hippocampus associated with hippocampus and cocaine
7) Confidence 0.70 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.08 Pain Relevance 0.54
A radioimmunoassay (RIA) study showed that a single dose of cocaine increased the TRH level in the striatum by 68%, but had no significant effect on the peptide content in the nucleus accumbens, hippocampus, amygdala, septum, hypothalamus, frontal and prefrontal cortex at 45 min after the drug injection.
Positive_regulation (increased) of TRH in nucleus accumbens associated with nucleus accumbens, hippocampus, amygdala and cocaine
8) Confidence 0.70 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.09 Pain Relevance 0.45
The data suggest an interaction of synaptic serotonin with a RX 77368-elicited event (activation of TRH receptors, second messenger systems and/or firing of the motor vagus) results in potentiation of the RX 77368-induced gastric response.
Positive_regulation (activation) of TRH associated with serotonin
9) Confidence 0.70 Published 1992 Journal Regul. Pept. Section Abstract Doc Link 1574606 Disease Relevance 0 Pain Relevance 0.60
By immunohistochemistry, we observed a pronounced and patterned increase in proTRH immunostaining in the striatum, with the strongest proTRH expression concentrated in the lateral and ventrolateral striatum including the sensorimotor striatum.
Positive_regulation (increase) of proTRH in striatum
10) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.45 Pain Relevance 0.29
We found a marked increase in the mRNA for preproTRH, which gives rise to TRH and several other fragments.
Positive_regulation (increase) of preproTRH
11) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.48 Pain Relevance 0.33
The effect of ethanol was also studied in primary culture of hypothalamic cells; a fast and transient increase in proTRH mRNA was observed at 1 h of incubation (0.001% final ethanol concentration).
Positive_regulation (increase) of proTRH
12) Confidence 0.70 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.47 Pain Relevance 0.39
After 1 h injection, TRH levels were increased in hippocampus and decreased in n. accumbens; after 4 h, it decreased in the hypothalamus, frontal cortex and amygdala, recovering to control values in all regions at 24 h.
Positive_regulation (increased) of TRH in frontal cortex associated with urological neuroanatomy, hippocampus and amygdala
13) Confidence 0.70 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.44 Pain Relevance 0.34
ProTRH mRNA levels increased at 1 h post-injection in total hypothalamus and hippocampus, while they decreased in the frontal cortex.
Positive_regulation (increased) of ProTRH in hippocampus associated with urological neuroanatomy and hippocampus
14) Confidence 0.70 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.49 Pain Relevance 0.36
Fourteen days of hypergravity (hyperG) exposure resulted in significant increases in thyrotropin-releasing hormone (TRH) content of brainstem and cerebellum, but no changes in levels of other neuropeptides (beta-endorphin, cholecystokinin, met-enkephalin, somatostatin, and substance P) examined in these areas were found, nor were TRH levels significantly changed in any other brain regions investigated.
Positive_regulation (increases) of TRH in brain associated with medulla, somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
15) Confidence 0.69 Published 1998 Journal Biol Signals Recept Section Abstract Doc Link 9873155 Disease Relevance 0 Pain Relevance 0.68
Rather, there is an increase only of TRH and that occurs only in areas of the brain known to be heavily involved with vestibular inputs and motor control (both voluntary and autonomic).
Positive_regulation (increase) of TRH in autonomic
16) Confidence 0.69 Published 1998 Journal Biol Signals Recept Section Abstract Doc Link 9873155 Disease Relevance 0 Pain Relevance 0.71
Fourteen days of hypergravity (hyperG) exposure resulted in significant increases in thyrotropin-releasing hormone (TRH) content of brainstem and cerebellum, but no changes in levels of other neuropeptides (beta-endorphin, cholecystokinin, met-enkephalin, somatostatin, and substance P) examined in these areas were found, nor were TRH levels significantly changed in any other brain regions investigated.
Positive_regulation (increases) of thyrotropin-releasing hormone in brain associated with medulla, somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
17) Confidence 0.69 Published 1998 Journal Biol Signals Recept Section Abstract Doc Link 9873155 Disease Relevance 0 Pain Relevance 0.68
Such increases in the TRH content tended to persist for 7 days, but returned to the control level 21 days after the last convulsion.
Positive_regulation (increases) of TRH associated with convulsion
18) Confidence 0.69 Published 1988 Journal No To Shinkei Section Abstract Doc Link 2465012 Disease Relevance 0.46 Pain Relevance 0.87
In IDPN-treated rats, TRH and CCK-8 levels were increased in the nucleus accumbens, and the frontal cortical CCK-8 level was extremely increased.
Positive_regulation (increased) of TRH in nucleus accumbens associated with nucleus accumbens
19) Confidence 0.69 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 7536949 Disease Relevance 0.15 Pain Relevance 0.73
In normal controls TRH-IR rose 120-180 min after glucose ingestion from 33 +/- 5 to 64 +/- 20 fmol/ml, while no increase in TRH-IR levels was observed in patients with SEI.
Neg (no) Positive_regulation (increase) of TRH-IR
20) Confidence 0.68 Published 1992 Journal Hepatogastroenterology Section Abstract Doc Link 1459520 Disease Relevance 0.54 Pain Relevance 0.55

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