INT137795

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 4.74
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1)
endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
brains 3
cleavage 1
BACE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.1 28 99.58 Very High Very High Very High
sodium channel 693 99.52 Very High Very High Very High
nMDA receptor 4 98.80 Very High Very High Very High
ischemia 8 97.64 Very High Very High Very High
Inflammation 9 88.72 High High
Glutamate 7 74.68 Quite High
cytokine 1 73.04 Quite High
cINOD 9 60.16 Quite High
imagery 14 13.68 Low Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 100.00 Very High Very High Very High
Injury 7 99.64 Very High Very High Very High
Disease Progression 8 99.60 Very High Very High Very High
Disease 158 99.58 Very High Very High Very High
Stress 25 98.96 Very High Very High Very High
Brain Injury 7 98.52 Very High Very High Very High
Cv Unclassified Under Development 8 97.64 Very High Very High Very High
Neuroblastoma 21 96.36 Very High Very High Very High
Alzheimer's Dementia 38 93.40 High High
Adhesions 7 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACE1 levels are also increased in some injury conditions including brain trauma [29] and ischemia [30-32], suggesting a possible role of BACE1 as a stress-response protein [2].
Positive_regulation (increased) of BACE1 in brain associated with stress, ischemia, injury and brain injury
1) Confidence 0.68 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.68 Pain Relevance 0.55
In a follow-up study, we showed that elevated BACE1 activity increased release of Nav?
Positive_regulation (elevated) of BACE1 associated with sodium channel
2) Confidence 0.68 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.26 Pain Relevance 0.61
In a follow-up study, we showed that elevated BACE1 activity increased release of Nav?
Positive_regulation (increased) of BACE1 associated with sodium channel
3) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.26 Pain Relevance 0.64
2 reported here would also alter sodium channel metabolism in various stress conditions including oxidative stress and mitochondrial dysfunctions, which are known to increase BACE1 levels.


Positive_regulation (increase) of BACE1 associated with stress and sodium channel
4) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.79 Pain Relevance 0.49
2 and Nav1.1 protein levels were elevated in BACE1-transgenic mouse brains and eventually resulted in altered sodium current densities in hippocampal neurons.
Positive_regulation (elevated) of BACE1-transgenic in brains associated with targeted disruption and nav1.1
5) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.28 Pain Relevance 0.70
In our previous studies, we have found that elevated BACE1-mediated cleavage of human Nav?
Positive_regulation (elevated) of BACE1 in cleavage associated with sodium channel
6) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.62
2 suggests the interesting possibility that BACE1 might modulate sodium channel metabolism not only in AD but also in other disease conditions in which BACE1 levels are increased.
Positive_regulation (increased) of BACE1 associated with sodium channel and disease
7) Confidence 0.40 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.71 Pain Relevance 0.41
The expression and enzymatic activity of BACE1 are increased in brains of AD patients.
Positive_regulation (increased) of BACE1 in brains associated with disease
8) Confidence 0.32 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.27 Pain Relevance 0.14
Bis-tacrine also has BACE-1 inhibitory action and blocks NMDA receptors, that provides it with an additional neuroprotective action [177].
Positive_regulation (has) of BACE-1 associated with nmda receptor
9) Confidence 0.28 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.51 Pain Relevance 0.16

General Comments

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