INT137796

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.92
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1)
endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
cleavage 1
BACE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 98.78 Very High Very High Very High
Inflammation 4 90.36 High High
Arthritis 1 64.72 Quite High
Disease Link Frequency Relevance Heat
Disease 15 99.28 Very High Very High Very High
INFLAMMATION 7 98.66 Very High Very High Very High
Alzheimer's Dementia 15 97.52 Very High Very High Very High
Aging 2 93.48 High High
Stress 2 91.12 High High
Cognitive Disorder 4 82.16 Quite High
Increased Venous Pressure Under Development 1 69.12 Quite High
Amyloid Plaque 1 57.56 Quite High
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to this hypothesis, both cholesterol and the examined compounds stimulated the beta-secretase cleavage of APP, resulting in a massive increase of secreted amyloid-beta peptides.
Regulation (stimulated) of beta-secretase in cleavage associated with alzheimer's dementia
1) Confidence 0.41 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.57 Pain Relevance 0.10
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Regulation (regulation) of BACE1 associated with disease
2) Confidence 0.31 Published 2006 Journal Prog. Neurobiol. Section Title Doc Link 16904810 Disease Relevance 1.18 Pain Relevance 0.12
Moreover, recent evidence indicates that beneficial effects of non-steriodal anti-inflammatory drugs on the progression of AD are mediated--at least in part--by effects on the peroxisome proliferator-activated receptor-gamma response element present in the BACE1 promoter.
Regulation (effects) of BACE1 associated with inflammation, cinod and disease
3) Confidence 0.19 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.17 Pain Relevance 0.18

General Comments

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