INT137797

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.15
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1)
endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
cleavage 2
brains 2
B104 2
BACE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 297 99.60 Very High Very High Very High
Inflammation 2 90.20 High High
ischemia 3 88.28 High High
cINOD 1 60.16 Quite High
Nav1.1 12 41.84 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 9 99.72 Very High Very High Very High
Disease 19 99.58 Very High Very High Very High
Alzheimer's Dementia 17 94.88 High High
Cognitive Disorder 2 92.08 High High
Stress 10 90.56 High High
INFLAMMATION 3 90.20 High High
Cv Unclassified Under Development 3 88.28 High High
Brain Injury 3 87.56 High High
Injury 3 86.20 High High
Disease Progression 3 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2 were transfected into B104 rat neuroblastoma cells stably overexpressing BACE1. ?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of BACE1 in B104 associated with neuroblastoma
1) Confidence 0.59 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.10 Pain Relevance 0.69
The expression and enzymatic activity of BACE1 are increased in brains of AD patients.
Positive_regulation (increased) of Gene_expression (expression) of BACE1 in brains associated with disease
2) Confidence 0.48 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.28 Pain Relevance 0.14
Q is the major BACE1 cleavage site of mouse Nav?
Positive_regulation (major) of Gene_expression (site) of BACE1 in cleavage associated with sodium channel
3) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.06 Pain Relevance 0.75
2 suggests the interesting possibility that BACE1 might modulate sodium channel metabolism not only in AD but also in other disease conditions in which BACE1 levels are increased.
Positive_regulation (increased) of Gene_expression (levels) of BACE1 associated with sodium channel and disease
4) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.71 Pain Relevance 0.41

General Comments

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