INT137811

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.22
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
Anatomy Link Frequency
nerve 1
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 11 100.00 Very High Very High Very High
Enkephalin 3 99.90 Very High Very High Very High
Hypoesthesia 1 99.58 Very High Very High Very High
methadone 135 95.80 Very High Very High Very High
withdrawal 24 86.24 High High
Dopamine 1 76.08 Quite High
Serotonin 3 75.68 Quite High
Abstinence syndrome 34 75.12 Quite High
Neurotransmitter 2 74.92 Quite High
Opioid 52 71.68 Quite High
Disease Link Frequency Relevance Heat
Hypesthesia 1 99.58 Very High Very High Very High
Cancer 58 98.12 Very High Very High Very High
Malignant Neoplastic Disease 4 97.36 Very High Very High Very High
Prostate Cancer 5 96.52 Very High Very High Very High
Breast Cancer 68 96.04 Very High Very High Very High
Apoptosis 49 90.88 High High
Opiate Addiction 27 86.24 High High
Newborn Drug Withdrawal Syndrome 37 75.12 Quite High
Disease 10 75.00 Quite High
Mycobacterium Infection 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Negative_regulation (lost) of NGFR associated with malignant neoplastic disease, nerve growth factor and prostate cancer
1) Confidence 0.50 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.68 Pain Relevance 0.38
Hypoesthesia was associated with decreased NGFr (81.8%) and PGP staining (90.9%).
Negative_regulation (decreased) of NGFr associated with hypoesthesia
2) Confidence 0.27 Published 2006 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 16906282 Disease Relevance 0.37 Pain Relevance 0.17
Acetylcholine, enkephalin and nerve growth factor are also reduced at birth following exposure during pregnancy [123, 319, 366, 399].


Negative_regulation (reduced) of nerve growth factor in nerve associated with nerve growth factor and enkephalin
3) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0.23 Pain Relevance 0.73
These data suggest that blocking both ER and growth factor receptor pathways could provide effective control over tumour growth in long-term oestrogen-deprived human breast cancers [27].
Negative_regulation (blocking) of growth factor receptor associated with cancer and breast cancer
4) Confidence 0.05 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.95 Pain Relevance 0

General Comments

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