INT137819

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.78
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
immune cell 1
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 18 97.90 Very High Very High Very High
chemokine 13 94.24 High High
opioid receptor 94 92.20 High High
cytokine 7 90.16 High High
Opioid 127 86.08 High High
imagery 32 82.96 Quite High
antagonist 11 80.00 Quite High
Endogenous opioid 37 72.88 Quite High
cINOD 2 68.68 Quite High
Enkephalin 17 61.76 Quite High
Disease Link Frequency Relevance Heat
Death 18 100.00 Very High Very High Very High
Apoptosis 73 99.64 Very High Very High Very High
Sepsis 13 85.08 High High
Staphylococcus Infection 2 75.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 74.76 Quite High
INFLAMMATION 71 68.44 Quite High
Hypersensitivity 1 64.80 Quite High
Syndrome 2 62.60 Quite High
Pain 37 56.12 Quite High
Necrosis 36 43.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine directly upregulates immune cell Fas receptors that trigger apoptosis of the cell when activated by the ligand FasL (Yin et al 1999).
FasL Binding (ligand) of in immune cell associated with apoptosis and morphine
1) Confidence 0.09 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.25 Pain Relevance 1.40
Since 1988, intravenous immunoglobulin (IVIG) has been shown to interfere with the interaction of Fas and FasL, and can be used as a treatment for TEN.
FasL Binding (interaction) of
2) Confidence 0.07 Published 2006 Journal Semin Cutan Med Surg Section Abstract Doc Link 16908399 Disease Relevance 0.74 Pain Relevance 0.07
Previous studies have shown that through an interaction with the death receptor CD95 induces apoptosis by formation of a signaling complex at the cell membrane and subsequent caspase-8 and caspase-3 activation [26].
CD95 Binding (interaction) of associated with apoptosis and death
3) Confidence 0.01 Published 2005 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998881 Disease Relevance 0.80 Pain Relevance 0.04

General Comments

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