INT137827

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 1 89.20 High High
Central nervous system 14 82.64 Quite High
Eae 2 37.20 Quite Low
Hippocampus 10 23.76 Low Low
Pyramidal cell 2 6.68 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 100 97.80 Very High Very High Very High
Aging 8 89.76 High High
Neuritis 1 89.20 High High
Targeted Disruption 4 85.48 High High
Amyloid Plaque 8 84.40 Quite High
Neuropathic Pain 3 80.16 Quite High
Neuroblastoma 4 79.04 Quite High
Congenital Anomalies 6 70.00 Quite High
Toxicity 3 57.32 Quite High
Stress 8 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical characterization by western blotting revealed that 1 and 5 mM concentrations of TOCP significantly inhibited the expression of neurofilament high molecular weight protein (NF-H), and that 5 mM TOCP inhibited expression of microtubule-associated protein 2c and tau protein, but not beta-actin.
Negative_regulation (inhibited) of Gene_expression (expression) of tau
1) Confidence 0.57 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16909309 Disease Relevance 0.32 Pain Relevance 0.09
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Negative_regulation (Impaired) of Gene_expression (levels) of Tau
2) Confidence 0.41 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.07 Pain Relevance 0.04

General Comments

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