INT137846

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.62
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3 100.00 Very High Very High Very High
allodynia 1 90.48 High High
Cancer pain 1 86.84 High High
rheumatoid arthritis 3 79.16 Quite High
antagonist 5 50.00 Quite Low
Potency 5 43.16 Quite Low
Bioavailability 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 116 99.82 Very High Very High Very High
Osteoporosis 38 99.56 Very High Very High Very High
Pain 2 98.56 Very High Very High Very High
Bone Cancer 6 97.48 Very High Very High Very High
Cancer 11 91.04 High High
Disease 7 83.36 Quite High
Hypercalcemia 33 81.48 Quite High
Rheumatoid Arthritis 3 79.16 Quite High
Overweight 6 75.00 Quite High
Obesity 3 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that HEP extract might inhibit osteoclastogenesis via the modulation of the OPG/RANKL system in osteoblastic cells.
Spec (might) Regulation (modulation) of RANKL associated with osteoporosis
1) Confidence 0.48 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.32 Pain Relevance 0
Effects of the RANKL inhibitor, osteoprotegerin, on the pain and histopathology of bone cancer in rats.
Regulation (Effects) of RANKL associated with pain and bone cancer
2) Confidence 0.44 Published 2006 Journal Clin. Exp. Metastasis Section Title Doc Link 16912914 Disease Relevance 0.29 Pain Relevance 0.38
Thus, the effect of vitamin D on BMD, serum OPG and RANKL were only secondary endpoints, most of the included subjects were not vitamin D deficient, and serum 1,25(OH)2D was not measured.
Regulation (effect) of RANKL
3) Confidence 0.24 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.35 Pain Relevance 0.04
In the present study we found no significant associations for serum 25(OH)D with BMD, serum OPG or serum RANKL at baseline after adjustment for confounders, nor did vitamin D supplementation for one year differ form placebo regarding change in BMD, serum OPG or serum RANKL.
Regulation (change) of RANKL
4) Confidence 0.21 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.08 Pain Relevance 0
After one year, no significant differences were found between the three groups regarding change in BMD, serum OPG or RANKL.


Regulation (change) of RANKL
5) Confidence 0.21 Published 2010 Journal Nutr J Section Abstract Doc Link PMC2818614 Disease Relevance 0.07 Pain Relevance 0
B, whereas 7-day treatment resulted in an inhibitory effect as previously reported [10].Fig. 4Effect of RSV and its analogues on RANKL-mediated NF-?
Regulation (analogues) of RANKL associated with respiratory syncytial virus
6) Confidence 0.19 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.51 Pain Relevance 0

General Comments

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