INT137847

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Anatomy Link Frequency
joint 1
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 77 98.96 Very High Very High Very High
rheumatoid arthritis 5 79.20 Quite High
epidural 1 63.68 Quite High
Pain 11 50.00 Quite Low
cytokine 3 43.20 Quite Low
Inflammation 12 9.24 Low Low
Acupuncture 1 7.68 Low Low
positron emission tomography 1 7.36 Low Low
psoriasis 19 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 67 98.96 Very High Very High Very High
Disease 37 89.84 High High
Osteoporosis 10 80.48 Quite High
Multiple Myeloma 29 79.92 Quite High
Rheumatoid Arthritis 7 79.20 Quite High
Aseptic Necrosis Of Bone 2 75.96 Quite High
Toxicity 2 66.84 Quite High
Psoriasis 22 64.96 Quite High
Bone Cancer 12 50.00 Quite Low
Pain 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another antiresorptive therapy involving the inhibition of RANKL by a monoclonal antibody (denosumab) is currently the subject of clinical investigations [46].
Negative_regulation (inhibition) of RANKL
1) Confidence 0.42 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2905716 Disease Relevance 0.51 Pain Relevance 0.03
CONCLUSIONS: RANKL inhibition with OPG reduced bone resorption and bone pain in rats with malignant bone disease; further study is warranted to determine if RANKL inhibition has similar benefits in humans.


Negative_regulation (inhibition) of RANKL
2) Confidence 0.41 Published 2006 Journal Clin. Exp. Metastasis Section Body Doc Link 16912914 Disease Relevance 0 Pain Relevance 0
Thus, both serum OPG and RANKL have been found to decrease after treatment with oestrogen in postmenopausal women in one study [28], whereas serum OPG but not RANKL increased after oral contraceptives in another study [29].
Negative_regulation (decrease) of RANKL
3) Confidence 0.38 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.23 Pain Relevance 0.04
Consistent with the work of Ritchlin et al. [12], our study also implicates RANKL in the pathogenesis of bone erosion in PsA, noting the modest correlation between circulating RANKL concentrations and measures of peripheral-joint bone loss.
Negative_regulation (loss) of RANKL in joint associated with arthritis
4) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.57 Pain Relevance 0.17

General Comments

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