INT137850

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.68
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PKD2) endoplasmic reticulum (PKD2) plasma membrane (PKD2)
cilium (PKD2) transmembrane transport (PKD2) cytoplasm (PKD2)
Anatomy Link Frequency
cilium 2
cilia 1
epithelial cells 1
melanocytes 1
keratinocytes 1
PKD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanosensation 4 97.60 Very High Very High Very High
TRP channel 20 90.84 High High
ASIC 2 87.80 High High
unmyelinated 1 75.20 Quite High
Inflammation 15 69.28 Quite High
Mechanotransduction 1 65.04 Quite High
melanocortin 1 receptor 2 63.92 Quite High
Pain 19 53.04 Quite High
fibrosis 6 52.48 Quite High
qutenza 48 51.44 Quite High
Disease Link Frequency Relevance Heat
Autosomal Dominant Polycystic Kidney 288 100.00 Very High Very High Very High
Disease 146 100.00 Very High Very High Very High
Cerebral Aneurysm 20 97.12 Very High Very High Very High
Renal Failure 4 95.08 Very High Very High Very High
Cyst 92 94.60 High High
Chronic Renal Failure 81 93.88 High High
Stress 4 93.88 High High
Congenital Anomalies 18 92.80 High High
Acidosis 2 91.72 High High
Polycystic Kidney Disease 107 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene PKD2 mutations, encoding the polycystin-2 protein, result in ADPKD type II (ADPKD2), corresponding to 15% of ADPKD cases [15].
Gene_expression (result) of PKD2 associated with autosomal dominant polycystic kidney
1) Confidence 0.65 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.48 Pain Relevance 0.07
The protein possibly participates in the signal-transduction pathway by coordinating with polycystin-2, the product of PKD2, in mediating mechanosensory calcium mobilization by function as flow-sensitive mechanosensors in the primary cilium of renal epithelium [10].
Gene_expression (product) of PKD2 in cilium
2) Confidence 0.55 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.91 Pain Relevance 0
The protein possibly participates in the signal-transduction pathway by coordinating with polycystin-2, the product of PKD2, in mediating mechanosensory calcium mobilization by function as flow-sensitive mechanosensors in the primary cilium of renal epithelium [10].
Gene_expression (product) of polycystin-2 in cilium
3) Confidence 0.48 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.92 Pain Relevance 0
Two known genes are responsible for this disease: PKD1 (MIM# 601313) at 16p13.3 [3-6] and PKD2 (MIM# 173910) at 4q21-23 [7].
Gene_expression (responsible) of PKD2 associated with disease
4) Confidence 0.48 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.99 Pain Relevance 0
Polycystin-1 (PC-1), polycystin-2 (PC-2) and other cystoproteins (not shown) are expressed in primary cilia, basal bodies or centrosomes.
Gene_expression (expressed) of PC-2 in cilia
5) Confidence 0.38 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.27 Pain Relevance 0.13
TRPP1 and TRPP2 were originally identified during the study of autosomal dominant polycystic kidney disease, an inherited disorder which is the most common cause of renal failure in humans.
Gene_expression (identified) of TRPP2 in kidney associated with renal failure, autosomal dominant polycystic kidney and disease
6) Confidence 0.23 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.59 Pain Relevance 0.05
Human epidermal keratinocytes and melanocytes express proopiomelanocortins (POMC) and all of the enzymes for POMC processing, i.e. prohormone convertases PC-1 and PC-2 including the regulatory protein 7B2.
Gene_expression (express) of PC-2 in melanocytes
7) Confidence 0.16 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.06
Both polycystin-1 and polycystin-2 are present in the primary cilium of tubular epithelial cells [20].
Gene_expression (present) of polycystin-2 in epithelial cells
8) Confidence 0.14 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.16 Pain Relevance 0.05
Other acid-sensitive channels include TRPV4, TRPC4, TRPC5, TRPP2 (PKD2L1), ionotropic purinoceptors (P2X), inward rectifier K(+) channels, voltage-activated K(+) channels, L-type Ca(2+) channels, hyperpolarization-activated cyclic nucleotide gated channels, gap junction channels, and Cl(-) channels.
Gene_expression (include) of TRPP2
9) Confidence 0.05 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 19655111 Disease Relevance 0.35 Pain Relevance 0.21
Human epidermal keratinocytes and melanocytes express proopiomelanocortins (POMC) and all of the enzymes for POMC processing, i.e. prohormone convertases PC-1 and PC-2 including the regulatory protein 7B2.
Gene_expression (express) of PC-2 in keratinocytes
10) Confidence 0.05 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.06

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