INT137857

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (SCG5) transport (SCG5) extracellular region (SCG5)
Anatomy Link Frequency
brain 1
SCG5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 7 99.36 Very High Very High Very High
Somatostatin 7 92.00 High High
Opioid 7 91.12 High High
orphanin 2 91.12 High High
opioid receptor 2 90.36 High High
Analgesic 4 88.40 High High
narcan 5 85.20 High High
Neuropeptide 5 84.56 Quite High
adenocard 1 15.44 Low Low
antagonist 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 7 99.84 Very High Very High Very High
Amyloid Plaque 1 96.24 Very High Very High Very High
Increased Venous Pressure Under Development 6 94.12 High High
Nociception 5 83.40 Quite High
Growth Problems 5 68.64 Quite High
Cognitive Disorder 1 67.72 Quite High
Appetite Loss 13 65.04 Quite High
Pancreatic Cancer 1 36.08 Quite Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Targeted Disruption 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PC2 levels were also increased, whereas, those of prodynorphin and pro7B2/7B2 were not changed in AD.
Neg (not) Positive_regulation (changed) of 7B2 associated with alzheimer's dementia
1) Confidence 0.49 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16914231 Disease Relevance 0.80 Pain Relevance 0.61
This model does not include pituitary ghrelin, which is downregulated by excessive thyroxine, glucocorticoid, or brain-GH feedback and upregulated by GHRH [42].
Positive_regulation (upregulated) of pituitary in brain
2) Confidence 0.49 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.13 Pain Relevance 0.09
The serum levels of ACTH and endorphin in SG VII were not significantly increased in comparison with the SG V control.
Neg (not) Positive_regulation (increased) of SG V
3) Confidence 0.45 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400409 Disease Relevance 0.08 Pain Relevance 0.18

General Comments

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