INT137873

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.52
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Artn) extracellular region (Artn)
Anatomy Link Frequency
DRG 1
Artn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 99.36 Very High Very High Very High
qutenza 10 98.04 Very High Very High Very High
dorsal root ganglion 6 97.32 Very High Very High Very High
Nerve growth factor 14 96.44 Very High Very High Very High
Hyperalgesia 6 83.80 Quite High
Thermal hyperalgesia 4 80.88 Quite High
nociceptor 6 75.00 Quite High
agonist 2 73.60 Quite High
IPN 2 66.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.36 Very High Very High Very High
Ganglion Cysts 6 97.32 Very High Very High Very High
Hyperalgesia 10 83.80 Quite High
Inflammatory Pain 2 66.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A corresponding increase in mRNA for the artemin coreceptor GFRalpha3 (for GDNF family receptor alpha) was seen in DRG, and GFRalpha3 immunoreactivity was widely colocalized with TRPV1 in epidermal afferents.
Positive_regulation (increase) of artemin in DRG associated with dorsal root ganglion
1) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16914685 Disease Relevance 0.76 Pain Relevance 1.37
Using reverse transcriptase-PCR, we found that artemin mRNA was profoundly upregulated in response to inflammation induced by hindpaw injection of complete Freund's adjuvant (CFA): artemin expression increased 10-fold 1 d after CFA injection, whereas NGF expression doubled by day 7.
Positive_regulation (upregulated) of artemin associated with nerve growth factor and inflammation
2) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16914685 Disease Relevance 0.76 Pain Relevance 1.26

General Comments

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