INT13790

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 52
Total Number 53
Disease Relevance 18.83
Pain Relevance 17.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
brain 4
neuronal 2
epidermal cells 1
hippocampal formation 1
cortex 1
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 113 100.00 Very High Very High Very High
antagonist 73 100.00 Very High Very High Very High
Serotonin 61 100.00 Very High Very High Very High
Dopamine 40 100.00 Very High Very High Very High
Migraine 25 99.84 Very High Very High Very High
antidepressant 76 99.80 Very High Very High Very High
Inflammation 9 99.44 Very High Very High Very High
5HT 283 99.42 Very High Very High Very High
substance P 18 99.24 Very High Very High Very High
opioid receptor 3 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine Without Aura 1 99.84 Very High Very High Very High
Frailty 16 99.80 Very High Very High Very High
Hypoglycemia 4 99.76 Very High Very High Very High
INFLAMMATION 9 99.44 Very High Very High Very High
Suicidal Behaviour 733 99.30 Very High Very High Very High
Headache 29 99.20 Very High Very High Very High
Gastric Motility Disorder 1 99.12 Very High Very High Very High
Anxiety Disorder 211 98.96 Very High Very High Very High
Pain 11 98.90 Very High Very High Very High
Appetite Loss 1 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively).
5-HT1A Binding (affinity) of
1) Confidence 0.47 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1982326 Disease Relevance 0 Pain Relevance 0.12
Repeated restraint stress in rats for 3 weeks causes changes in the hippocampal formation that include suppression of 5-HT1A receptor binding and atrophy of dendrites of CA3 pyramidal neurons, as well as impairment of initial learning of a radial arm maze task.
5-HT1A Binding (binding) of in hippocampal formation associated with stress, pyramidal cell and frailty
2) Confidence 0.47 Published 1997 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 9405958 Disease Relevance 1.29 Pain Relevance 0.43
BACKGROUND: We investigated the frequencies of the symptoms such as "ataxia, depression, insomnia, anorexia, and pain," that have been reported to be associated with 5-HT1A receptor, and the effect of tandospirone citrate (tandospirone: 5-HT1A agonist) in patients with Machado-Joseph disease (MJD).
5-HT1A Binding (associated) of associated with appetite loss, pain, ataxia, depression, machado-joseph disease, agonist and sleep disorders
3) Confidence 0.47 Published 2004 Journal Clin Neuropharmacol Section Abstract Doc Link 15090930 Disease Relevance 0.66 Pain Relevance 0.20
PHARMACOLOGICAL PROPERTIES: Aripiprazole is a quinolinone derivative with a high affinity for dopamine D2 and D3 receptors, and serotonin 5-HT1A, 5-HT2A and 5-HT2B receptors.
5-HT1A Binding (affinity) of associated with dopamine and serotonin
4) Confidence 0.47 Published 2004 Journal Drugs Section Abstract Doc Link 15257633 Disease Relevance 0.54 Pain Relevance 0.33
The results of this study suggest that serotonergic 5HT1A receptors may interact with hypoglycemia in the stimulation of OT, but not AVP secretion.
5HT1A Neg (not) Binding (interact) of associated with hypoglycemia
5) Confidence 0.47 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8771561 Disease Relevance 0.36 Pain Relevance 0.57
In addition, we estimated the potencies of 5-HT receptor ligands in inhibiting specific [3H]5-HT binding (in the presence of 8-hydroxy-2(di-n-propylamino)tetralin and mesulergine to prevent binding to 5-HT1A and 5-HT2C sites) to guinea-pig cortical synaptosomes and membranes. 5-HT receptor agonists inhibited the K(+)-evoked tritium overflow from synaptosomes and slices.
5-HT1A Binding (binding) of associated with agonist
6) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692282 Disease Relevance 0 Pain Relevance 0.23
Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response.
5-HT1A Binding (Association) of associated with antidepressant
7) Confidence 0.47 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Title Doc Link 15447813 Disease Relevance 0.40 Pain Relevance 0.67
F 11356 has subnanomolar affinity for cloned human and nonhuman 5-HT1B and 5-HT1D receptors, and its affinity for 5-HT1A and other 5-HT receptors, including the 5-ht1F subtype, is 50-fold lower and micromolar, respectively.
5-HT1A Binding (affinity) of
8) Confidence 0.47 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381763 Disease Relevance 0.13 Pain Relevance 0.15
To better define the profiles of these compounds as potential antidepressants, binding affinity for 5-HT1A receptors and alpha2-adrenoceptors was also investigated by competition experiments using [3H]8-hydroxy-2-(dipropylamino)tetralin ([3H]8-OH-DPAT) and [3H]rauwolscine as radiolabelled ligands, respectively.
5-HT1A Binding (affinity) of associated with antidepressant
9) Confidence 0.47 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17910821 Disease Relevance 0 Pain Relevance 0.22
The only pharmacological property shared by both agents is high affinity for 5-HT1D and 5-HT1A receptors.
5-HT1A Binding (affinity) of
10) Confidence 0.47 Published 1989 Journal Headache Section Abstract Doc Link 2547733 Disease Relevance 0.10 Pain Relevance 0.43
Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response.
5-HT1A Binding (Interaction) of associated with antidepressant and serotonin
11) Confidence 0.47 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 18725263 Disease Relevance 0.09 Pain Relevance 0.33
CONCLUSIONS: Changes in interaction between 5-HT1A receptor system and the endogenous opioid system may play a role both in the mechanism of action and response to antidepressant drugs.


5-HT1A Binding (interaction) of
12) Confidence 0.47 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
In addition to binding to 5-HT1A and 5-HT2A receptors, flibanserin binds with moderate affinity to the dopamine D4 receptors.
5-HT1A Binding (binding) of associated with dopamine
13) Confidence 0.47 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 0.63 Pain Relevance 0.18
Further, 5-HT-containing boutons have been shown to make synaptic contact with cardiac vagal motoneurons (CVMs), and there is also a high density of 5-HT1A binding in the brain nuclei containing these CVMs.
5-HT1A Binding (binding) of in brain
14) Confidence 0.47 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1702490 Disease Relevance 0.07 Pain Relevance 0.38
In nonalcoholic suicides, there is a localized increase in 5-HT1A binding in ventral prefrontal cortex, hypothesized to be a response to less serotonin input which had been hypothesized to be related to increased impulsivity and emotional dysregulation [161].
5-HT1A Binding (binding) of in cortex associated with suicidal behaviour, attention deficit hyperactivity disorder and serotonin
15) Confidence 0.47 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 1.30 Pain Relevance 0.28
Underwood et al. [160], using quantitative autoradiographic experiments in human postmortem brain tissue, found that binding to 5-HT1A receptors is lower in both alcoholic suicides and nonsuicides; so they suggested that this effect might be related to alcoholism and not to suicide.
5-HT1A Binding (binding) of in brain associated with alcohol addiction and suicidal behaviour
16) Confidence 0.47 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 1.21 Pain Relevance 0.35
Since tegaserod has affinity for the 5-HT1 receptor, it is plausible that tegaserod could cause the same types of cardiovascular adverse events seen with agents prescribed for management of migraine.
5-HT1 receptor Binding (affinity) of associated with migraine
17) Confidence 0.39 Published 2004 Journal Pharmacotherapy Section Abstract Doc Link 15098809 Disease Relevance 0.79 Pain Relevance 0.47
Previously we have shown that in vitro, 5HT1A receptor binding to a radioactive agonist can be modulated by specific intensity and frequency electromagnetic fields (EMFs).
5HT1A Binding (binding) of associated with agonist
18) Confidence 0.38 Published 2003 Journal Biomed Sci Instrum Section Abstract Doc Link 12724937 Disease Relevance 0.58 Pain Relevance 0.47
Oxymetazoline was recognized with nanomolar affinity by 5-HT1A, 5-HT1B and 5-HT1D binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests.
5-HT1A Binding (recognized) of associated with potency
19) Confidence 0.36 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1678720 Disease Relevance 0 Pain Relevance 0.34
On the basis of the long-term clinical experience with sexual side-effects of many antidepressants, flibanserin, a novel centrally acting compound with both 5HT2 antagonism and 5HT1a agonism81 is currently investigated to assess safety and efficacy in a large phase III clinical trial program (the Bouquet study program) involving over 5,000 premenopausal women with generalized acquired HSDD, recruited both in North America and Europe.
5HT1a Binding (compound) of in Bouquet associated with antidepressant and hypoactive sexual desire disorder
20) Confidence 0.36 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 0.47 Pain Relevance 0.16

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