INT137903

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SH3PXD2B) cytoplasm (SH3PXD2B)
Anatomy Link Frequency
gut 2
SH3PXD2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 98.60 Very High Very High Very High
nud 4 94.12 High High
spastic colon 2 72.00 Quite High
antagonist 2 55.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 98.60 Very High Very High Very High
Disease 4 95.76 Very High Very High Very High
Diarrhoea 4 95.20 Very High Very High Very High
Constipation 2 94.80 High High
Dyspepsia 4 94.12 High High
Congenital Anomalies 2 80.16 Quite High
Gastrointestinal Disease 2 78.64 Quite High
Inflammatory Bowel Disease 2 74.32 Quite High
Functional Bowel Disorder 2 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases.
Gene_expression (expressed) of TKs in gut associated with inflammation, nud and disease
1) Confidence 0.64 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16918330 Disease Relevance 0.69 Pain Relevance 0.16
Pathophysiological implications of TKs in the digestive tract include changes in TK innervation, in the expression of TKs and TK receptors, which result in inflammation- and immune-induced disturbances of gut functions, such as dysmotility (diarrhoea/constipation), secretory diarrhoea and visceral hyperalgesia.
Gene_expression (expression) of TKs in gut associated with constipation, diarrhoea, inflammation and nud
2) Confidence 0.64 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16918330 Disease Relevance 1.06 Pain Relevance 0.33

General Comments

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