INT137905

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TKT) small molecule metabolic process (TKT) nucleolus (TKT)
peroxisome (TKT) nucleus (TKT) carbohydrate metabolic process (TKT)
Anatomy Link Frequency
gut 1
TKT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 97.08 Very High Very High Very High
nud 2 95.48 Very High Very High Very High
spastic colon 1 68.96 Quite High
antagonist 3 52.56 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 97.12 Very High Very High Very High
INFLAMMATION 2 97.08 Very High Very High Very High
Dyspepsia 2 95.48 Very High Very High Very High
Diarrhoea 2 93.68 High High
Constipation 1 93.28 High High
Congenital Anomalies 1 77.12 Quite High
Gastrointestinal Disease 1 75.60 Quite High
Inflammatory Bowel Disease 1 71.28 Quite High
Functional Bowel Disorder 1 68.96 Quite High
Neuroblastoma 6 39.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pathophysiological implications of TKs in the digestive tract include changes in TK innervation, in the expression of TKs and TK receptors, which result in inflammation- and immune-induced disturbances of gut functions, such as dysmotility (diarrhoea/constipation), secretory diarrhoea and visceral hyperalgesia.
Regulation (changes) of TK in gut associated with constipation, diarrhoea, inflammation and nud
1) Confidence 0.13 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16918330 Disease Relevance 1.05 Pain Relevance 0.32
As shown in Figure 2A, expression of DREAM did not significantly affect the activity of the empty TK reporter, confirming previous results (2).
Neg (not) Regulation (affect) of TK reporter
2) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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