INT137906

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.55
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
lungs 2
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 100.00 Very High Very High Very High
Morphine 7 99.88 Very High Very High Very High
Opioid 23 94.96 High High
fluoxetine 2 93.92 High High
antagonist 17 86.24 High High
fibrosis 17 83.04 Quite High
Serotonin 2 83.00 Quite High
Inflammatory response 1 73.84 Quite High
agonist 9 71.52 Quite High
adenocard 2 64.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 96 98.00 Very High Very High Very High
Fibrosis 19 97.32 Very High Very High Very High
Hypertension 8 92.68 High High
Gastrointestinal Stromal Tumor 78 89.20 High High
Glioma 22 84.88 Quite High
Pulmonary Fibrosis 8 83.84 Quite High
Chromosome Aberrations 2 80.32 Quite High
INFLAMMATION 9 73.84 Quite High
Malignant Neoplastic Disease 5 72.88 Quite High
Radiation Sickness 2 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of PDGFRbeta may occur through oxidation of a catalytic cysteine of tyrosine phosphatase. 5-HT-activated PDGFRbeta phosphorylation is blocked by the antioxidant N-acetyl-L-cysteine and the NADPH oxidase inhibitor, DPI.
Positive_regulation (5-HT-activated) of Phosphorylation (phosphorylation) of PDGFRbeta
1) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.22 Pain Relevance 0.13
Inhibition of PDGFR kinase with imatinib or AG1296 blocks 5-HT-stimulated PDGFRbeta phosphorylation. 5-HTT inhibitors and the Na+/K+-ATPase inhibitor ouabain, but not 5-HT2 and 5-HT1B/1D receptor inhibitors, block PDGFRbeta activation by 5-HT.
Positive_regulation (5-HT-stimulated) of Phosphorylation (phosphorylation) of PDGFRbeta
2) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.27 Pain Relevance 0.12
In addition morphine also stimulated MOR associated PDGF-beta receptor phosphorylation.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PDGF-beta receptor associated with mu opioid receptor and morphine
3) Confidence 0.33 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.97
The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of PDGFR in lungs
4) Confidence 0.24 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.94 Pain Relevance 0.28
Activating mutations of PDGFR?
Positive_regulation (Activating) of Phosphorylation (mutations) of PDGFR
5) Confidence 0.22 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.98 Pain Relevance 0.03
M, neither DSLET, DADLE, nor DPDPE were found to increase the tyrosine phosphorylation of the IR or the PDGFR, whereas insulin (100 ng/ml) or PDGF (50 ng/ml) induced significant tyrosine phosphorylation of these sites (Figure 8).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PDGFR
6) Confidence 0.19 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.14 Pain Relevance 0.40

General Comments

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