INT137907

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.78
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Ephb2) kinase activity (Ephb2)
Anatomy Link Frequency
spinal cord 2
Ephb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 16 99.68 Very High Very High Very High
Pain 154 98.40 Very High Very High Very High
Morphine 11 98.22 Very High Very High Very High
Analgesic 46 91.36 High High
agonist 1 85.24 High High
antagonist 10 83.52 Quite High
mu opioid receptor 8 81.28 Quite High
Opioid 26 75.60 Quite High
nMDA receptor 6 62.80 Quite High
bradykinin 2 56.80 Quite High
Disease Link Frequency Relevance Heat
Pain 160 98.40 Very High Very High Very High
Cancer 152 97.94 Very High Very High Very High
Pancreatic Cancer 34 78.80 Quite High
Skin Cancer 16 53.12 Quite High
Neuropathic Pain 18 49.28 Quite Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Bone Cancer 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine stimulates mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and Akt phosphorylation in a time dependent manner like VEGF in mREC.
Phosphorylation (phosphorylation) of ERK associated with morphine
1) Confidence 0.61 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.90
production from cancer-inoculated regions induces the gene expression of ephrin B1 in DRGs, which then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord, finally leading to pain.
Phosphorylation (phosphorylation) of Eph B receptor in spinal cord associated with pain, cancer and spinal cord
2) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.45 Pain Relevance 0.97
production in cancer-inoculated regions induces ephrin B1 gene expression in DRGs and then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord.
Phosphorylation (phosphorylation) of Eph B receptor in spinal cord associated with cancer and spinal cord
3) Confidence 0.21 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.32 Pain Relevance 1.09

General Comments

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