INT137908

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Context Info
Confidence 0.81
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.44
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
lungs 2
smooth muscle cells 1
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 99.76 Very High Very High Very High
Morphine 7 99.36 Very High Very High Very High
Opioid 23 94.08 High High
fluoxetine 2 93.32 High High
fibrosis 51 88.16 High High
antagonist 21 86.24 High High
Serotonin 2 82.36 Quite High
Inflammatory response 3 78.96 Quite High
Inflammation 19 74.40 Quite High
agonist 9 70.48 Quite High
Disease Link Frequency Relevance Heat
Ring Chromosomes 30 98.44 Very High Very High Very High
Gastrointestinal Stromal Tumor 98 98.16 Very High Very High Very High
Cancer 451 98.00 Very High Very High Very High
Fibrosis 57 97.32 Very High Very High Very High
Glioma 40 94.84 High High
Apoptosis 5 94.72 High High
Malignant Neoplastic Disease 28 92.88 High High
Hypertension 9 92.04 High High
Disease 143 90.64 High High
Pulmonary Fibrosis 24 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of PDGFR kinase with imatinib or AG1296 blocks 5-HT-stimulated PDGFRbeta phosphorylation. 5-HTT inhibitors and the Na+/K+-ATPase inhibitor ouabain, but not 5-HT2 and 5-HT1B/1D receptor inhibitors, block PDGFRbeta activation by 5-HT.
Phosphorylation (phosphorylation) of PDGFRbeta
1) Confidence 0.81 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.27 Pain Relevance 0.12
Activation of PDGFRbeta may occur through oxidation of a catalytic cysteine of tyrosine phosphatase. 5-HT-activated PDGFRbeta phosphorylation is blocked by the antioxidant N-acetyl-L-cysteine and the NADPH oxidase inhibitor, DPI.
Phosphorylation (phosphorylation) of PDGFRbeta
2) Confidence 0.80 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.22 Pain Relevance 0.13
In addition morphine also stimulated MOR associated PDGF-beta receptor phosphorylation.
Phosphorylation (phosphorylation) of PDGF-beta receptor associated with mu opioid receptor and morphine
3) Confidence 0.55 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.96
In addition, both imatinib and nilotinib inhibited the phosphorylation of PDGFR-alpha tyrosine kinase with equivalent efficacy (Verstovsek et al 2006b).
Phosphorylation (phosphorylation) of PDGFR-alpha tyrosine kinase
4) Confidence 0.53 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.16 Pain Relevance 0
Sorafenib also inhibited PDGFR autophosphorylation in primary human aortic smooth muscle cells (HAoSMCs); Flt-3 was also sensitive to inhibition of receptor phosphorylation by sorafenib in cell-based assays.
Phosphorylation (autophosphorylation) of PDGFR in smooth muscle cells
5) Confidence 0.44 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.70 Pain Relevance 0
On the one hand, treatment with imatinib/gleevec disrupted an autocrine PDGF/PDGFR loop by specifically inhibiting phosphorylation of PDGFR and thus exerted a synergistic antitumoral effect with ionising radiation as radiosensitizer [54].
Phosphorylation (phosphorylation) of PDGFR
6) Confidence 0.40 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.15 Pain Relevance 0.10
The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.
Phosphorylation (phosphorylation) of PDGFR in lungs
7) Confidence 0.40 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.00 Pain Relevance 0.28
The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.
Phosphorylation (phosphorylation) of PDGFR in lungs
8) Confidence 0.40 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.94 Pain Relevance 0.28
Activating mutations of PDGFR?
Phosphorylation (mutations) of PDGFR
9) Confidence 0.35 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.98 Pain Relevance 0.03
M, neither DSLET, DADLE, nor DPDPE were found to increase the tyrosine phosphorylation of the IR or the PDGFR, whereas insulin (100 ng/ml) or PDGF (50 ng/ml) induced significant tyrosine phosphorylation of these sites (Figure 8).
Phosphorylation (phosphorylation) of PDGFR
10) Confidence 0.30 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.14 Pain Relevance 0.40
In a seminal paper phosphorylation level of PDGFR?
Phosphorylation (phosphorylation) of PDGFR
11) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.24 Pain Relevance 0
As described previously pretreatment phosphorylation levels of PDGFR-?
Phosphorylation (phosphorylation) of PDGFR
12) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 1.30 Pain Relevance 0
COX-2 protein and mRNA overexpression was detected in all 14 cases, together with the expression and phosphorylation of PDGFRA and PDGFRB, which in turn paralleled the presence of their cognate ligands.
Phosphorylation (phosphorylation) of PDGFRB
13) Confidence 0.11 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.93 Pain Relevance 0.14
phosphorylation was at least 10-fold lower than the PDGFR?
Phosphorylation (phosphorylation) of PDGFR
14) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.42 Pain Relevance 0

General Comments

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