INT137918

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Pdgfrb) plasma membrane (Oprm1, Pdgfrb) signal transducer activity (Oprm1, Pdgfrb)
nucleus (Pdgfrb) kinase activity (Pdgfrb) lysosome (Pdgfrb)
Anatomy Link Frequency
endothelial cells 4
endothelium 1
Oprm1 (Mus musculus)
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 40 100.00 Very High Very High Very High
agonist 5 99.20 Very High Very High Very High
Morphine 35 98.88 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that mu opioid receptor (MOR) transactivates Flk1 and platelet-derived growth factor-beta (PDGF-beta) receptors and its agonist morphine stimulates pro-angiogenic and survival-promoting signaling in mouse retinal endothelial cells (mREC).
MOR Positive_regulation (transactivates) of platelet-derived growth factor-beta in endothelial cells associated with agonist, mu opioid receptor and morphine
1) Confidence 0.41 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.60
Here we show that mu opioid receptor (MOR) transactivates Flk1 and platelet-derived growth factor-beta (PDGF-beta) receptors and its agonist morphine stimulates pro-angiogenic and survival-promoting signaling in mouse retinal endothelial cells (mREC).
mu opioid receptor Positive_regulation (transactivates) of platelet-derived growth factor-beta in endothelial cells associated with agonist, mu opioid receptor and morphine
2) Confidence 0.41 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.60
Here we show that mu opioid receptor (MOR) transactivates Flk1 and platelet-derived growth factor-beta (PDGF-beta) receptors and its agonist morphine stimulates pro-angiogenic and survival-promoting signaling in mouse retinal endothelial cells (mREC).
MOR Positive_regulation (transactivates) of PDGF-beta in endothelial cells associated with agonist, mu opioid receptor and morphine
3) Confidence 0.36 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.60
Here we show that mu opioid receptor (MOR) transactivates Flk1 and platelet-derived growth factor-beta (PDGF-beta) receptors and its agonist morphine stimulates pro-angiogenic and survival-promoting signaling in mouse retinal endothelial cells (mREC).
mu opioid receptor Positive_regulation (transactivates) of PDGF-beta in endothelial cells associated with agonist, mu opioid receptor and morphine
4) Confidence 0.36 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.60
These data suggest that MOR associates and transactivates RTKs for Flk1 and PDGF-beta, which may have a compounding effect on angiogenic signaling in endothelium.
MOR Positive_regulation (transactivates) of PDGF-beta in endothelium associated with mu opioid receptor
5) Confidence 0.29 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.91

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