INT137944

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
macrophages 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 2 99.70 Very High Very High Very High
Migraine 3 99.16 Very High Very High Very High
Inflammation 4 98.02 Very High Very High Very High
Pain 1 93.92 High High
Disease Link Frequency Relevance Heat
Headache 2 99.16 Very High Very High Very High
INFLAMMATION 4 98.02 Very High Very High Very High
Fever 1 94.32 High High
Pain 1 93.92 High High
Epilepsy 1 78.00 Quite High
Disease 1 77.44 Quite High
Migraine Without Aura 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings substantiate the hypothesis of transitory delayed inflammation, as suggested by the animal model, and suggest the possibility of using therapeutic approaches to target NF-kappaB transcription in the treatment of migraine.
Regulation (target) of Transcription (transcription) of NF-kappaB associated with inflammation and migraine
1) Confidence 0.45 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16919057 Disease Relevance 0.43 Pain Relevance 0.30
Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages.
Regulation (regulation) of Transcription (transcription) of nuclear factor kappa B in macrophages associated with cox2
2) Confidence 0.36 Published 2010 Journal Cell. Signal. Section Title Doc Link 20546888 Disease Relevance 0.44 Pain Relevance 0.28

General Comments

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