INT137958

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Asprv1) plasma membrane (Pdyn)
Asprv1 (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Kappa opioid receptor 2 99.16 Very High Very High Very High
antinociception 6 97.80 Very High Very High Very High
Enkephalin 2 94.00 High High
antagonist 4 84.56 Quite High
intrathecal 1 69.60 Quite High
tail-flick 1 68.88 Quite High
Antinociceptive 1 64.92 Quite High
nociceptor 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that TAPS mainly stimulates mu(1)-opioid receptors, which subsequently induce the release of dynorphin B, which then acts on kappa-opioid receptors to produce antinociception.
TAPS Positive_regulation (induce) of Localization (release) of dynorphin B associated with antinociception, dynorphin, kappa opioid receptor and opioid receptor
1) Confidence 0.21 Published 2006 Journal Peptides Section Abstract Doc Link 16919848 Disease Relevance 0 Pain Relevance 1.43

General Comments

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