INT137960

Context Info Confidence 0.67 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 6.50 Pain Relevance 2.34

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG) plasma membrane (FASLG) cell-cell signaling (FASLG)

Anatomy Link Frequency CAR 1 skin 1 NK cells 1 T cells 1 FASLG (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 42 99.36 Migraine 152 99.20 Paracetamol 11 98.88 Analgesic 3 94.84 Arthritis 1 92.96 cytokine 38 85.28 rheumatoid arthritis 156 81.76 Multiple sclerosis 2 70.84 Potency 1 55.36 Calcium channel 11 55.28

Disease Link Frequency Relevance Heat Death 21 99.96 Apoptosis 88 99.74 Staphylococcus Infection 128 99.66 Bullous Skin Disease 106 99.58 INFLAMMATION 46 99.36 Migraine Disorders 92 99.20 Chronic Periodontitis 3 96.04 Neurodegenerative Disease 2 92.96 Arthritis 2 92.96 Diabetes Mellitus 2 92.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, several potential mechanisms are proposed for this antiangiogenic activity, including the generation of free radicals such as superanions and nitric oxide [26] and upregulation of the Fas/FASL system.

Positive_regulation (upregulation) of FASL

1) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2862241 Disease Relevance 0.49 Pain Relevance 0.03

In human hepatocytes (HEPG-2) and in human primary cultures of normal liver cells, APAP, but not 5a, was associated with apoptotic cell death, Fas-ligand up-regulation, and CAR (constitutive androstane receptor) activation, contributing to a favorable safety profile of 5a as an orally delivered analgesic.

Positive_regulation (up-regulation) of Fas-ligand in CAR associated with paracetamol, analgesic, apoptosis and death

2) Confidence 0.45 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16919959 Disease Relevance 0.37 Pain Relevance 0.96

In addition, IL-18 also activates the proliferation of activated T cells and their production of IL-2 and granulocyte/macrophage-colony-stimulating factor, and the cytotoxic activity of NK cells through up-regulation of Fas ligand [15].

Positive_regulation (up-regulation) of Fas ligand in NK cells

3) Confidence 0.45 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.32 Pain Relevance 0.29

It appears clear now that increased levels of sFasL can be found in the serum of patients with SJS/TEN, and levels of sFasL are consistently elevated when analysis is performed preceding skin detachment [48].

Positive_regulation (elevated) of FasL in skin associated with staphylococcus infection and bullous skin disease

4) Confidence 0.45 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.35 Pain Relevance 0.04

Despite a potential neurological role, our results provided no evidence for a role for this FasL genetic variant in migraine.

Positive_regulation (role) of FasL associated with migraine

5) Confidence 0.44 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.51 Pain Relevance 0.43

All PCR reactions for each SNP and the FasL marker utilized final concentrations of MgCl2,Primers, dNTPs, 10 × Buffer and Taq polymerase with 1.75 mM, 0.2 ?

Positive_regulation (reactions) of FasL

6) Confidence 0.44 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 0.13 Pain Relevance 0.12

These T cells are unusually resistant to apoptosis in SF that contains a significant amount of pro-apoptotic factors such as bioactive FasL, TRAIL and TNF-?

Positive_regulation (bioactive) of FasL in T cells associated with apoptosis

7) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.10 Pain Relevance 0.29

Positive staining for active caspase-3, Fas, FasL and p53 in the inflammatory infiltrates was only observed in the inflammatory infiltrate from the chronic periodontitis biopsies, whereas Bcl-2-positive cells was present in the tissues from both groups.

Positive_regulation (Positive) of FasL associated with chronic periodontitis and inflammation

8) Confidence 0.14 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.23 Pain Relevance 0.17

General Comments

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