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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.50
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
skin 1
NK cells 1
T cells 1
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 42 99.36 Very High Very High Very High
Migraine 152 99.20 Very High Very High Very High
Paracetamol 11 98.88 Very High Very High Very High
Analgesic 3 94.84 High High
Arthritis 1 92.96 High High
cytokine 38 85.28 High High
rheumatoid arthritis 156 81.76 Quite High
Multiple sclerosis 2 70.84 Quite High
Potency 1 55.36 Quite High
Calcium channel 11 55.28 Quite High
Disease Link Frequency Relevance Heat
Death 21 99.96 Very High Very High Very High
Apoptosis 88 99.74 Very High Very High Very High
Staphylococcus Infection 128 99.66 Very High Very High Very High
Bullous Skin Disease 106 99.58 Very High Very High Very High
INFLAMMATION 46 99.36 Very High Very High Very High
Migraine Disorders 92 99.20 Very High Very High Very High
Chronic Periodontitis 3 96.04 Very High Very High Very High
Neurodegenerative Disease 2 92.96 High High
Arthritis 2 92.96 High High
Diabetes Mellitus 2 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, several potential mechanisms are proposed for this antiangiogenic activity, including the generation of free radicals such as superanions and nitric oxide [26] and upregulation of the Fas/FASL system.
Positive_regulation (upregulation) of FASL
1) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2862241 Disease Relevance 0.49 Pain Relevance 0.03
In human hepatocytes (HEPG-2) and in human primary cultures of normal liver cells, APAP, but not 5a, was associated with apoptotic cell death, Fas-ligand up-regulation, and CAR (constitutive androstane receptor) activation, contributing to a favorable safety profile of 5a as an orally delivered analgesic.
Positive_regulation (up-regulation) of Fas-ligand in CAR associated with paracetamol, analgesic, apoptosis and death
2) Confidence 0.45 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16919959 Disease Relevance 0.37 Pain Relevance 0.96
In addition, IL-18 also activates the proliferation of activated T cells and their production of IL-2 and granulocyte/macrophage-colony-stimulating factor, and the cytotoxic activity of NK cells through up-regulation of Fas ligand [15].
Positive_regulation (up-regulation) of Fas ligand in NK cells
3) Confidence 0.45 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.32 Pain Relevance 0.29
It appears clear now that increased levels of sFasL can be found in the serum of patients with SJS/TEN, and levels of sFasL are consistently elevated when analysis is performed preceding skin detachment [48].
Positive_regulation (elevated) of FasL in skin associated with staphylococcus infection and bullous skin disease
4) Confidence 0.45 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.35 Pain Relevance 0.04
Despite a potential neurological role, our results provided no evidence for a role for this FasL genetic variant in migraine.
Positive_regulation (role) of FasL associated with migraine
5) Confidence 0.44 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.51 Pain Relevance 0.43
All PCR reactions for each SNP and the FasL marker utilized final concentrations of MgCl2,Primers, dNTPs, 10 × Buffer and Taq polymerase with 1.75 mM, 0.2 ?
Positive_regulation (reactions) of FasL
6) Confidence 0.44 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 0.13 Pain Relevance 0.12
These T cells are unusually resistant to apoptosis in SF that contains a significant amount of pro-apoptotic factors such as bioactive FasL, TRAIL and TNF-?
Positive_regulation (bioactive) of FasL in T cells associated with apoptosis
7) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.10 Pain Relevance 0.29
Positive staining for active caspase-3, Fas, FasL and p53 in the inflammatory infiltrates was only observed in the inflammatory infiltrate from the chronic periodontitis biopsies, whereas Bcl-2-positive cells was present in the tissues from both groups.
Positive_regulation (Positive) of FasL associated with chronic periodontitis and inflammation
8) Confidence 0.14 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.23 Pain Relevance 0.17

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