INT137967

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.29
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 4
nerve 4
brain 2
bladder 2
dorsal root ganglia 2
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 10 100.00 Very High Very High Very High
Lasting pain 7 99.32 Very High Very High Very High
Pain 142 98.08 Very High Very High Very High
unmyelinated 2 97.84 Very High Very High Very High
TRP channel 45 97.72 Very High Very High Very High
Nerve growth factor 7 97.16 Very High Very High Very High
qutenza 238 94.00 High High
addiction 2 86.40 High High
Spinal cord 18 85.76 High High
Neurotransmitter 9 85.60 High High
Disease Link Frequency Relevance Heat
Pain 150 99.32 Very High Very High Very High
Bladder Disease 80 99.32 Very High Very High Very High
Nervous System Injury 4 98.92 Very High Very High Very High
Overactive Bladder 58 96.24 Very High Very High Very High
Injury 4 92.60 High High
Frailty 6 85.76 High High
Stress Incontinence 10 83.80 Quite High
Central Nervous System Disease 2 73.48 Quite High
Demyelinating Disease 6 69.84 Quite High
Hypersensitivity 21 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPM8 expression was increased in a subset of sensory neurons after nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 in nerve
1) Confidence 0.70 Published 2006 Journal Curr. Biol. Section Body Doc Link 16920620 Disease Relevance 0.08 Pain Relevance 0
Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury.
Positive_regulation (Increased) of Gene_expression (expression) of TRPM8 in dorsal root ganglia associated with nervous system injury
2) Confidence 0.49 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17517374 Disease Relevance 0.47 Pain Relevance 0.37
If it is, axon terminal expression of TRPM8 could also be useful for probing functional connections between neurons of disparate brain regions.
Positive_regulation (useful) of Gene_expression (expression) of TRPM8 in brain
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.05 Pain Relevance 0.18
TRPM8 transfection
Positive_regulation (transfection) of Gene_expression (transfection) of TRPM8
4) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0 Pain Relevance 0.34
To determine if expression of heterologous ion channels alters synaptic properties of cultured hippocampal neurons, we transfected neurons in microisland culture with TRPV1 or TRPM8.
Positive_regulation (transfected) of Gene_expression (transfected) of TRPM8 in neurons
5) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.05 Pain Relevance 0.19
TRPM8 expression was detected in the smooth muscle cells of the rat vas deference with preferential localization of the TRPM8 protein to the membrane of sarcoplasmic reticulum (SR).
Positive_regulation (detected) of Gene_expression (expression) of TRPM8 in reticulum
6) Confidence 0.47 Published 2009 Journal Fiziol Zh Section Abstract Doc Link 20201386 Disease Relevance 0 Pain Relevance 0.11
TRPM8 (subtype melastatin 8), is expressed in a distinct subset of nociceptors, and activated by cool temperature (<25°C), menthol, icilin [45,46], and the carboxyamide derivative WS-12 [47].
Positive_regulation (activated) of Gene_expression (expressed) of TRPM8 in nociceptors associated with nociceptor
7) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.46 Pain Relevance 0.53
In a recent study, we demonstrated an increased expression of TRPM8 in suburothelial nerve fibres of patients with painful bladder syndrome (PBS) and idiopathic detrusor overactivity (IDO) [6].
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 in nerve associated with pain, overactive bladder and bladder disease
8) Confidence 0.36 Published 2006 Journal BMC Urol Section Body Doc Link PMC1766360 Disease Relevance 0.80 Pain Relevance 0.29
In a previous study [6], we demonstrated increased expression of TRPM8-immunoreactive nerve fibres in PBS bladder biopsies, with a significant correlation of these fibres with pain.
Positive_regulation (increased) of Gene_expression (expression) of TRPM8-immunoreactive in bladder associated with pain and bladder disease
9) Confidence 0.36 Published 2006 Journal BMC Urol Section Body Doc Link PMC1766360 Disease Relevance 1.13 Pain Relevance 0.57
Patch-clamp experiments revealed activation of a strongly outwardly rectifying, Ca2+ permeable cation current in TRPM8 overexpressing but not control cells, with strong similarities to the endogenous cold- and menthol-activated current in trigeminal neurons [68, 91].
Neg (not) Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TRPM8 in neurons
10) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.06 Pain Relevance 0.04
In HEK293 and CHO cells overexpressing TRPM8, menthol application dose-dependently increases intracellular Ca2+.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TRPM8
11) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.18 Pain Relevance 0.04

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