INT137968

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.90
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
horn 2
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 98.72 Very High Very High Very High
qutenza 20 93.60 High High
dorsal root ganglion 20 93.28 High High
Pain 13 84.80 Quite High
isoflurane 2 65.68 Quite High
Neuropathic pain 20 50.00 Quite Low
Inflammation 16 50.00 Quite Low
antagonist 11 50.00 Quite Low
analgesia 3 50.00 Quite Low
addiction 1 34.64 Quite Low
Disease Link Frequency Relevance Heat
Pain 14 98.28 Very High Very High Very High
Nociception 26 97.40 Very High Very High Very High
Ganglion Cysts 26 93.28 High High
Bladder Disease 3 83.20 Quite High
Overactive Bladder 4 82.04 Quite High
Myelodysplastic Syndromes 1 81.88 Quite High
Neuropathic Pain 26 50.00 Quite Low
INFLAMMATION 18 50.00 Quite Low
Hypersensitivity 34 40.68 Quite Low
Inflammatory Pain 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: We show that activation of TRPM8 in a subpopulation of sensory afferents (by either cutaneous or intrathecal application of specific pharmacological agents or by modest cooling) elicits analgesia in neuropathic and other chronic pain models in rats, thereby inhibiting the characteristic sensitization of dorsal-horn neurons and behavioral-reflex facilitation.
Negative_regulation (inhibiting) of Positive_regulation (activation) of TRPM8 in horn
1) Confidence 0.43 Published 2006 Journal Curr. Biol. Section Body Doc Link 16920620 Disease Relevance 0.10 Pain Relevance 0
AMTB inhibits icilin-induced TRPM8 channel activation as measured in a Ca(2+) influx assay, with a pIC(50) of 6.23.
Negative_regulation (inhibits) of Positive_regulation (icilin-induced) of TRPM8
2) Confidence 0.43 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18562636 Disease Relevance 0.49 Pain Relevance 0.19
A previous study performed on HEK cells expressing TRPM8 showed that 8-Br-cAMP and forskolin, two PKA activators, inhibited TRPM8 activity induced by menthol [23].
Negative_regulation (inhibited) of Positive_regulation (induced) of TRPM8
3) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.14 Pain Relevance 0.05
Thus, menthol produced robust activation of xlTRPM8 that was suppressed by a moderate rise in bath temperature (Fig. 4A), as observed for mammalian and avian receptors, where ligand and temperature gating show allosteric coupling.
Negative_regulation (suppressed) of Positive_regulation (activation) of xlTRPM8
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2683941 Disease Relevance 0 Pain Relevance 0.05
We found that HC-030031 did not block TRPM8 activation at concentrations up to 30 ?
Negative_regulation (block) of Positive_regulation (activation) of TRPM8
5) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.17 Pain Relevance 0.21

General Comments

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