INT137972

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.01
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RX7) cytoplasm (P2RX7)
Anatomy Link Frequency
macrophages 3
pancreas 1
brain 1
veins 1
microglial cells 1
P2RX7 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 13 100.00 Very High Very High Very High
antagonist 77 99.92 Very High Very High Very High
Inflammation 132 99.46 Very High Very High Very High
Pain 27 96.72 Very High Very High Very High
Neuropathic pain 11 91.68 High High
adenocard 36 91.64 High High
cytokine 23 88.40 High High
Spinal cord 96 86.68 High High
Hippocampus 11 85.84 High High
Inflammatory response 14 85.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 153 99.46 Very High Very High Very High
Death 40 99.04 Very High Very High Very High
Cancer 15 98.76 Very High Very High Very High
Increased Venous Pressure Under Development 63 97.84 Very High Very High Very High
Pancreatic Cancer 4 97.28 Very High Very High Very High
Hepatitis D Virus Infection 55 96.76 Very High Very High Very High
Pain 33 96.72 Very High Very High Very High
Injury 12 96.36 Very High Very High Very High
Disease 56 95.44 Very High Very High Very High
Targeted Disruption 37 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate a structural and functional interaction between P2X4 and P2X7, which suggests that they associate to form heteromeric receptors.
P2X7 Binding (interaction) of
1) Confidence 0.36 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.05 Pain Relevance 0.10
Here, we provide biochemical and electrophysiological evidence for an association between P2X4 and P2X7 that increases the diversity of receptor currents mediated via these two subtypes.
P2X7 Binding (association) of
2) Confidence 0.36 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.27 Pain Relevance 0.23
Having identified CL075 as an effective single stimulus mediating P2X7 receptor-independent IL-1?
P2X7 Binding (receptor) of
3) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.10
Heightened expression patterns and localization patterns of CD39, P2X7, and P2Y2 infer associations with chronic inflammation and neoplasia of the pancreas.
P2X7 Binding (associations) of in pancreas associated with inflammation and cancer
4) Confidence 0.31 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.24 Pain Relevance 0.32
In addition we tested the effect of oxidized ATP, oATP, a potent antagonist of P2X7 that acts by irreversible binding to the ATP-binding site [28].
P2X7 Binding (binding) of associated with antagonist
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 1.60 Pain Relevance 0.05
Although P2X7 ligation also led to macrophage death, the inhibition of PLD prevented chlamydial killing but had no effect on macrophage death, suggesting that PLD activation was directly responsible for the inhibition of chlamydial infection (Table 1).
P2X7 Binding (ligation) of in macrophage associated with chlamydia infection and death
6) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 1.13 Pain Relevance 0
The death of macrophages is partly necrotic, which may amplify inflammation even further, through the ligation of P2X7 receptors on other cells.
P2X7 Binding (ligation) of in macrophages associated with inflammation and death
7) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.92 Pain Relevance 0.17
This, coupled with the release of superoxide from microglial cells/macrophages following P2X7 ligation [43] suggests a pivotal role of microglial cells/macrophages in the degenerative processes associated with these diseases.
P2X7 Binding (ligation) of in macrophages associated with disease
8) Confidence 0.18 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.88 Pain Relevance 0.22
It has been suggested that cell lysis, consequent to P2X7 receptor-induced pore formation, contributes to the disorganisation and decrease in contractile myocytes in the media of varicose veins [157].
P2X7 receptor-induced Binding (formation) of in veins associated with increased venous pressure under development
9) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.85 Pain Relevance 0
Therefore, available P2X7 receptor antibodies either recognize a site, which is not the P2X7 receptor, or, as a recent study indicates [78], a brain analogue of the P2X7 receptor, which shares its antibody binding domain with the cloned P2X7 receptor and partially retains its functionality in P2X7 receptor knockout animals.


P2X7 receptor Binding (recognize) of in brain associated with targeted disruption
10) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.19 Pain Relevance 0.25
This, coupled with the release of superoxide from microglial cells/macrophages following P2X7 ligation [43] suggests a pivotal role of microglial cells/macrophages in the degenerative processes associated with these diseases.
P2X7 Binding (ligation) of in microglial cells associated with disease
11) Confidence 0.06 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.88 Pain Relevance 0.22
Compound 36, for example, a hybrid of a preferred LHS for P2X7 and RHS for KATP possesses potent activity at hP2X7 (pIC50?
hP2X7 Binding (example) of associated with potassium channel
12) Confidence 0.04 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.51

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