INT137976

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.74
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ENTPD1) plasma membrane (ENTPD1)
Anatomy Link Frequency
endothelial cells 1
platelet 1
heart 1
vascular endothelia 1
ENTPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 127 100.00 Very High Very High Very High
Inflammation 97 100.00 Very High Very High Very High
cva 4 100.00 Very High Very High Very High
aspirin 17 99.84 Very High Very High Very High
Chronic pancreatitis 6 99.64 Very High Very High Very High
fibrosis 2 96.88 Very High Very High Very High
ischemia 10 94.96 High High
Inflammatory mediators 2 90.24 High High
cytokine 19 87.08 High High
Hippocampus 8 86.80 High High
Disease Link Frequency Relevance Heat
Pancreatitis 12 99.64 Very High Very High Very High
Hypoxia 22 99.28 Very High Very High Very High
Neointima 15 98.68 Very High Very High Very High
Ischemic Heart Disease 6 98.68 Very High Very High Very High
Pancreatic Cancer 8 98.64 Very High Very High Very High
Disease 40 98.56 Very High Very High Very High
INFLAMMATION 93 97.44 Very High Very High Very High
Fibrosis 4 96.88 Very High Very High Very High
Myocardial Infarction 84 96.72 Very High Very High Very High
Frailty 2 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease.
Positive_regulation (Upregulation) of CD39 associated with inflammation and pancreatitis
1) Confidence 0.59 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 16920697 Disease Relevance 1.37 Pain Relevance 0.51
Transcripts of ectonucleotidases (CD39 and CD39L1) together with P2R (P2X7, P2Y2, and P2Y6) are significantly increased in both chronic pancreatitis and pancreatic cancer.
Positive_regulation (increased) of CD39 associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.42 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.45 Pain Relevance 0.44
There is a significant increase in ectonucleotidase activity (NTPDase1) in the hearts of patients with ischaemic heart disease [180] that could represent a compensatory mechanism against increased nucleotide levels during chronic ischaemia.
Positive_regulation (increase) of NTPDase1 in heart associated with ischemic heart disease and cv unclassified under development
3) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.04 Pain Relevance 0.03
Augmentation of NTPDase1 activity is an important adaptive response for cardiac allograft survival, with increased inflammation, platelet deposition and infarction rates in NTPDase-deficient mice [136].
Positive_regulation (Augmentation) of NTPDase1 in platelet associated with inflammation and infarction
4) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.20 Pain Relevance 0.09
Preconditioning delays the postischemic increase in ATP diphosphohydrolase activity [243].
Positive_regulation (increase) of ATP diphosphohydrolase associated with antagonist
5) Confidence 0.21 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.42 Pain Relevance 0.40
Newly developed vascular endothelia express very high levels of NTPDase1, also seen under hypoxic conditions [155].
Positive_regulation (levels) of NTPDase1 in vascular endothelia associated with hypoxia
6) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.72 Pain Relevance 0
Activity of ‘ecto-ATP diphosphohydrolase’ in human endothelial cells in-vitro is increased by aspirin [93] and glomerular ‘ecto-ATP diphosphohydrolase’ immunoreactivity might well be modulated by estradiol [94].
Positive_regulation (increased) of ecto-ATP diphosphohydrolase in endothelial cells associated with aspirin
7) Confidence 0.13 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.54 Pain Relevance 0.17

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