INT137977

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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 14
Disease Relevance 3.07
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
brain 5
cerebellum 2
pancreas 1
corneas 1
outer layer 1
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 10 99.08 Very High Very High Very High
Inflammation 10 98.68 Very High Very High Very High
Chronic pancreatitis 6 97.04 Very High Very High Very High
Hippocampus 60 95.72 Very High Very High Very High
medulla 10 95.40 Very High Very High Very High
amygdala 10 94.24 High High
Inflammatory mediators 2 90.28 High High
Pyramidal cell 60 90.04 High High
adenocard 60 86.32 High High
cva 4 85.28 High High
Disease Link Frequency Relevance Heat
Disease 2 99.60 Very High Very High Very High
INFLAMMATION 10 98.68 Very High Very High Very High
Pancreatic Cancer 8 98.52 Very High Very High Very High
Cancer 6 98.00 Very High Very High Very High
Pancreatitis 12 97.04 Very High Very High Very High
Cv General 3 Under Development 2 85.28 High High
Malignant Neoplastic Disease 2 83.88 Quite High
Frailty 2 83.44 Quite High
Fibrosis 4 83.08 Quite High
Injury 88 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior to that assay, corneas were treated to identify the localization of P2Y2-R.
Localization (localization) of P2Y2-R in corneas
1) Confidence 0.80 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.13 Pain Relevance 0
We have therefore defined tissue distribution and localization of the CD39 family of ectonucleotidases and associated P2R in human disease.
Localization (localization) of P2R associated with disease
2) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.33 Pain Relevance 0.43
Importantly, co-localization of A1R and P2Y2R in the cerebellum was observed in cell bodies, except in the nuclear region, in the Purkinje cells and those of the interposed cerebellar lobule nucleus (Figure 2D-I).
Localization (localization) of P2Y2R in cerebellum
3) Confidence 0.73 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.21
Co-immunoprecipitation of A1R and P2Y2R from rat brain
Localization (immunoprecipitation) of P2Y2R in brain
4) Confidence 0.68 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.23
Moreover, in these same regions, anti-A1Rs were capable of co-precipitating P2Y2R (Figure 3D), indicating that A1R and P2Y2R are associated with one another in rat cortex, cerebellum, and hippocampus.
Localization (precipitating) of P2Y2R in cortex associated with hippocampus
5) Confidence 0.68 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.21
Immunogold electron microscopic observations of A1R and P2Y2R expressed in rat brain
Localization (observations) of P2Y2R in brain
6) Confidence 0.68 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0
The characterization of antibodies for rat brain sections was previously reported, although the rabbit polyclonal anti-P2Y2R antibody (anti-P2Y2R; 1 ?
Localization (reported) of P2Y2R in brain
7) Confidence 0.68 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.11
In the present study, we visualized the surface expression and co-localization of A1R and P2Y2R in both transfected HEK293T cells and in rat brain by confocal microscopy and more precisely by immunogold electron microscopy.
Localization (localization) of P2Y2R in brain
8) Confidence 0.64 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC3009664 Disease Relevance 0.08 Pain Relevance 0.24
The co-localization of A1R and P2Y2R in co-transfected HEK293T cells was examined by double immunostaining of HA-A1R and Myc-P2Y2R as a comparison experiment for the localization of these receptors in brain tissues (Figure 2).
Localization (localization) of P2Y2R in brain
9) Confidence 0.64 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.04
Co-localization of A1R and P2Y2R in transfected HEK293T cells
Localization (localization) of P2Y2R
10) Confidence 0.64 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.04
Heightened expression patterns and localization patterns of CD39, P2X7, and P2Y2 infer associations with chronic inflammation and neoplasia of the pancreas.
Localization (localization) of P2Y2 in pancreas associated with inflammation and cancer
11) Confidence 0.61 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.40 Pain Relevance 0.35
As we can observe in Figure 2C, P2Y2-R signaling is localized only in the outer layer of the epithelium, this signal being higher in control corneas than in Ap4A-treated corneas 24 h after wounding (1481.93±34.20 for control and 1149.46±28.04 for Ap4A, p<0.001; Figure 2C, upper panel).
Localization (localized) of P2Y2-R in outer layer
12) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.14 Pain Relevance 0
Moreover, in these same regions, anti-A1Rs were capable of co-precipitating P2Y2R (Figure 3D), indicating that A1R and P2Y2R are associated with one another in rat cortex, cerebellum, and hippocampus.
Localization (precipitating) of P2Y2R in hippocampus associated with hippocampus
13) Confidence 0.23 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.21
Moreover, in these same regions, anti-A1Rs were capable of co-precipitating P2Y2R (Figure 3D), indicating that A1R and P2Y2R are associated with one another in rat cortex, cerebellum, and hippocampus.
Localization (precipitating) of P2Y2R in cerebellum associated with hippocampus
14) Confidence 0.23 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.21

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